Natural Products and Cancer Drug Discovery (notice n° 36353)
| 000 -LEADER | |
|---|---|
| fixed length control field | 03966nam a22005055i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-4614-4654-5 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211202164945.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 121116s2013 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781461446545 |
| -- | 978-1-4614-4654-5 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-4614-4654-5 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC261-271 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCL |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED062000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 614.5999 |
| Edition number | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Natural Products and Cancer Drug Discovery |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by Frank E. Koehn. |
| 264 #1 - | |
| -- | New York, NY : |
| -- | Springer New York : |
| -- | Imprint: Springer, |
| -- | 2013. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XII, 244 p. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content Type Term | text |
| Content Type Code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media Type Term | computer |
| Media Type Code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier Type Term | online resource |
| Carrier Type Code | cr |
| Source | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Cancer Drug Discovery and Development |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Preface.- The Impact of Natural Products upon Cancer Chemotherapy -- Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth -- Discodermolide: Past, Present and Future -- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents -- Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates -- Natural Product Scaffolds in Cancer Therapy -- The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery -- Accessing Anti-Cancer Natural Products by Plant Cell Culture -- Natural Products as Tools for Discovering New Cancer Targets -- Index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery. The historical record is strong, but what is the current impact of natural products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of future agents? This volume attempts to address this question through a series of chapters authored by leading researchers in the field which effectively provide an in-depth view of several high impact areas of natural products cancer research. The volume begins with a focused analysis and rationale for the clinical success of current natural product anti-cancer drugs. The following chapters then describe new natural product based drugs in three rapidly evolving target classes and modalities- agents which target tumor vasculature, inhibitors of histone deacetylase and other histone modifying enzymes, and antibody drug conjugates. Subsequent chapters examine the central role of natural product chemical scaffolds in the genesis of new anti-cancer therapeutics- first via the powerful application of chemical synthesis, and then through the rapidly emerging fields of biosynthetic engineering and plant cell culture. The volume concludes with an assessment of the critical role that natural products continue to play in the search for new cancer drug targets. As the reader makes his or her way through the volume it may become clear that there is strong evidence that natural products will continue to exert a profound positive impact on cancer drug discovery. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 9 (RLIN) | 87742 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer research. |
| 9 (RLIN) | 87743 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pharmacology. |
| 9 (RLIN) | 87744 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Oncology. |
| 9 (RLIN) | 87745 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 9 (RLIN) | 3969 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer Research. |
| 9 (RLIN) | 87746 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Oncology. |
| 9 (RLIN) | 87745 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pharmacology/Toxicology. |
| 9 (RLIN) | 87747 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Koehn, Frank E. |
| Relator term | editor. |
| 9 (RLIN) | 87748 |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 9 (RLIN) | 25138 |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9781461446538 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Cancer Drug Discovery and Development |
| 9 (RLIN) | 87749 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://dx.doi.org/10.1007/978-1-4614-4654-5">http://dx.doi.org/10.1007/978-1-4614-4654-5</a> |
| 912 ## - | |
| -- | ZDB-2-SME |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Ebook |
| 956 ## - LOCAL ELECTRONIC LOCATION AND ACCESS (OCLC) | |
| Electronic name | Springer |
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