Bibliothèque de L'IMIST/CNRST

Presents and discusses the advances that have been made in recent years in the understanding of the roles of the complement system in the maintenance of health and its participation in pathology. Topics are ordered in increasing complexity from basic molecular to human clinical, building the case for the ultimate message: time has come to find new ways to modulate the system in-vivo in order to make better use of its protective powers and to prevent its adverse effects in disease.

Includes bibliographical references and index.

The development of the "One-hit" of "Single Site" theory of complement mediated immune hemolysis a personal account / T. Borsos -- The initiation complexes of the classical and lectin pathways / P. Gal, et. al. -- Complement genetics / Gy. Abel and V. Agnello -- Regulation of complement receptor gene expression: Regulators and inhibitors / M. Tolnay and G.C. Tsokos -- Coordination of adaptive immune responses by C3 / A. Erdei, et. al. -- Terminal complement complex: Regulation of formation and pathophysiological functions / F. Tedesco, et. al. -- The many faces of the membrane regulators of complement / C.L. Harris and B.P. Morgan -- New insights into the regulation of complement activation by decay accelerating factor / L. Kuttner-Kondo and E.M. Medof -- The role of complement in pregnancy and fetal loss / G. Girardi and J.E. Salmon -- Complement deficiencies: a 2004 update / By. Abel and V. agnello

Microbial evasion mechanisms against human complement / R. Wurzner and P.F. Zipfel -- Complement-mediated antibody-dependent enhancement of viral infections / Z. Prohaszka, et.al. -- Tumor cell resistance to complement-mediated lysis / M. Kirschfink and Z. Fishelson -- Complement and autoimmunity / G.C. Tsokos and M. Tolnay -- The complex roles of anaphylatoxins in allergic asthma and autoimmune diseases / H. Hawlish, et. al. -- Role of complement in allergy / L. Varga, H. Farkas, and G. Fust -- Complement activation-related pseudoallergy: Mechanism of anaphylactoid reactions to radiocontrast media and drug carrier liposomes and micelles / J. Szebeni -- The role of complement in transplantation / M. Kirschfink and T.E. Mollnes

Role of complement in myocardial ischemia and infarction / M.C. Walsh, et. al. -- Role of complement in intestinal ischemia/reperfusion induced injury / S.D. Fleming and G. Tsokos -- Role of C5a and C5a receptor in sepsis / F.S. Zetoune, et. al. -- Role of complement in multi-organ dysfunction syndrome / M.S. Huber-Lang, et. al. -- Therepeutic manipulation of the complement system / T.E. Mollnes -- Activation and inhibition of complement by immunoglobulins / M. Basta -- Engineering control of complement inhibition at the cell surface / R.A.G. Smith, et. al.