Bibliothèque de L'IMIST/CNRST

Description based on print version of record.

Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. In this volume, researchers are encouraged to fully explore topics and research related to co-transport systems. The authors and editors associated with Current Topics in Membranes are recognized as world-renowned scientists in their respective fields, making this series one of the premier resources.

Includes bibliographical references and index.

Front Cover; Store-Operated Calcium Channels; Copyright; Contents; Contributors; Preface; Previous Volumes in Series; Chapter One: Store-Operated Orai Channels: Structure and Function; 1. Introduction; 2. Identification of the Orai Proteins; 3. STIM1 Is the ER Ca2+ Sensor for SOCE; 4. Orai1 Is the Pore-Forming Subunit of the CRAC Channel; 5. The CRAC Channel Is Essential for Lymphocyte Activation; 6. Oligomerization and Redistribution of STIM1 to the ER-Plasma Membrane Junctions; 7. Conformational Changes in STIM1; 8. STIM1 Directly Binds to Orai1; 9. Orai1 Domains Involved in STIM1 Binding

10. CRAC Channel Subunit Stoichiometry11. How Many STIM Molecules Does It Take to Activate CRAC Channels?; 12. Structural Basis of Selectivity and Permeation; 13. STIM1 Regulates CRAC Channel Ion Selectivity; 14. Regulation of CRAC Channels by Calcium; 14.1. Calcium-dependent potentiation; 14.2. Calcium-dependent fast inactivation; 15. Conclusions; Acknowledgments; References; Chapter Two: STIM-ORAI Interactions That Control the CRAC Channel; 1. Overview of STIM-ORAI Interactions; 1.1. Introduction; 1.2. Direct STIM-ORAI interaction; 1.3. Modulation by proteins

1.4. Modulation by phosphoinositides1.5. Comments on the assays; 1.6. Observations not explained solely by STIM-ORAI interaction; 2. The C-terminal Region of the ORAI Channel; 2.1. Truncations of ORAI C-terminus; 2.2. Mutations in ORAI C-terminus; 2.3. Interaction of STIM1 with the ORAI C-terminal region; 2.4. STIM binding to ORAI C-terminus in light of the ORAI crystal structure; 3. The N-terminal Region of the ORAI Channel; 3.1. ORAI N-terminal chimeras and truncations; 3.2. Transmembrane helix 1; 3.3. Interaction of STIM1 with the ORAI N-terminal region; 3.4. The SCID mutation R91W

3.5. Other mutations in ORAI1 residues 74-913.6. Possible structural basis of channel gating; 3.7. Calmodulin and CRACR2A; 3.8. ORAI1 N-terminal to residue 64; 4. Conclusion; Acknowledgments; References; Chapter Three: Structure and Function of Endoplasmic Reticulum STIM Calcium Sensors; 1. Introduction; 2. STIM and Orai Domain Architectures; 3. STIM1 and Orai1 in the Activation in SOCE; 4. Human STIM1 and STIM2 EF-SAM Biophysical Features; 5. Human STIM1 EF-SAM Structure; 6. Human STIM2 EF-SAM Structure; 7. Human STIM1 and STIM2 Cytosolic Domains; 8. STIM Coupling to Orai

9. Concluding RemarksAcknowledgments; References; Chapter Four: On the Stoichiometry of Resting and Activated CRAC Channels; 1. The Stoichiometry of Orai1; 2. The Stoichiometry of STIM1; 3. Summary; Acknowledgments; References; Chapter Five: Alternative Forms of the Store-Operated Calcium Entry Mediators, STIM1 and Orai1; 1. Store-Operated Channels; 2. STIM1 Phosphorylation in Mitosis; 3. Two Forms of Orai1; 4. Summary and Remaining Questions; Acknowledgment; References; Chapter Six: The ARC Channel-An Endogenous Store-Independent Orai Channel; 1. Introduction