Bibliothèque de L'IMIST/CNRST

Front Cover; Functional Organization of Vertebrate Plasma Membrane; Copyright; Contents; Contributors; Preface; References; Previous Volumes in Series; Current Topics in Membranes and Transport; Current Topics in Membranes; Chapter One: Spectrin- and Ankyrin-Based Membrane Domains and the Evolution of Vertebrates; 1. Introduction; 2. An Ancient Spectrin-Ankyrin Partnership for Coordinating Membrane-Spanning Proteins; 3. Diversification of Vertebrate Ankyrins and Spectrins; 4. Evolution of Spectrin-Ankyrin-Based Domains: Lessons from the Axon Initial Segment.

5. Functions of Spectrin and Ankyrin in Polarized Organelle Transport6. Summary and Perspectives; References; Chapter Two: The Human Erythrocyte Plasma Membrane: A Rosetta Stone for Decoding Membrane-Cytoskeleton Structure; 1. Introduction; 2. Overview of Spectrin-Actin Lattice Structure in the Membrane Skeleton; 3. History; 3.1. Discovery of actin filaments as linkers in the spectrin-actin lattice; 3.2. Actin filaments are nodes in a quasi-hexagonal symmetric spectrin-actin lattice; 3.3. Actin filament structures in the membrane skeleton in situ.

3.4. Actin filament capping restricts filament lengths in RBCs4. RBC Actin Filament Capping Proteins: Properties and Functions; 4.1. Tropomodulin1 (Tmod1) is the pointed end capper; 4.1.1. Tmod1 binds TM and actin to cap filament pointed ends; 4.1.2. Tmod1 regulates RBC actin filament lengths and membrane skeleton integrity in vivo; 4.1.3. Significance; 4.2. Adducin is the barbed end capper; 4.2.1. Adducin caps barbed ends and recruits spectrin to actin; 4.2.2. Adducin stabilizes the RBC membrane skeleton in vivo; 4.2.3. Significance; 4.3. Capping protein (EcapZ) also caps barbed ends in RBCs.

5. RBC Actin Filament Side-Binding Proteins5.1. Tropomyosin (TM) stabilizes actin filaments; 5.1.1. TM regulation of actin filament length and stability; 5.1.2. TM regulation of RBC actomyosin ATPase; 5.2. Dematin: A role for actin filament bundling?; 5.2.1. Dematin bundles actin filaments; 5.2.2. Dematin stabilizes the RBC membrane skeleton in vivo; 6. Are RBC Actin Filaments Dynamic?; 7. Conclusions and Future Directions; Acknowledgments; References; Chapter Three: Membrane Protein Dynamics and Functional Implications in Mammalian Cells; 1. Introduction; 2. The Fluid Mosaic Model and Beyond.

3. Techniques for Measuring Lateral Mobility of Membrane Proteins4. Membrane Protein Dynamics in Mammalian Cells; 4.1. Red cell membrane protein dynamics; 4.1.1. Band 3; 4.1.2. Glycophorins; 4.1.3. Complement components; 4.1.4. Aquaporins; 4.1.5. Toward a model of functional organization; 4.2. Membrane protein dynamics in other hematopoietic cells; 4.2.1. Erythroblasts; 4.2.2. Lymphocytes; 4.2.3. Common themes of functional organization in hematopoietic cells; 4.3. Membrane protein dynamics in non-hematopoietic cells; 4.3.1. Neurons; 4.3.2. Endothelial cells; 4.3.3. Epithelial cells.

4.3.4. Common themes of functional organization in non-hematopoietic cells.

Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume covers recent breakthroughs in understanding the molecular and cellular basis for patterning vertebrate plasma membranes. A special emphasis is placed on physiological function with chapters covering signaling in the nervous system and heart, vision, and the immune system.

Description based on print version record.