Bibliothèque de L'IMIST/CNRST

Includes bibliographical references and index.

General introduction to robustness / Age K. Smilde -- Stability and response surface methodology / Stephen P. Jones -- Review of the use of robustness and ruggedness in analytical chemistry / Y. Vander Heyden, D.L. Massart -- Robustness criteria. Incorporating robustness explicitly in optimization procedures utilizing multicriteria methods / Jan H. de Boer -- Ruggedness tests for analytical chemistry / Mary Mulholland -- Stabilizing a TLC separation illustrated by a mixture of several street drugs / C.A.A. Duineveld, P. Koopmans, P.M.J. Coenegracht -- Robustness of liquid-liquid extraction of drugs from biological samples / Jacob Wieling -- The use of a factorial design to evaluate the physical stability of tablets after storage under tropical conditions / C.E. Bos, G.K. Bolhuis, A.K. Smilde, J.H. de Boer.

In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given. Features of this book: and bull; Gives a good overview of mathematical and statistical methods used in two application areas, id est pharmaceutical technology and analytical chemistry and bull; Illustrates the different approaches available to attain robustness and bull; Gives ideas on how to use methods in practical situations. The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures.

Description based on print version record.