Bibliothèque de L'IMIST/CNRST

The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.

I. Introduction. -- Evolutionary aspects for the neuroendocrine immune network and ageing (R.H. Straub). -- II. Ageing of the immune system. -- Immunosenescence (R. Solana, G. Pawelec). Zinc-binding proteins (metallothionein and [alpha]-2 macroglobulin) as potential biological markers of immunosenescence (E. Mocchegiani and others). Neutrophil ageing and immunosenescence (S.K. Butcher and others). Apoptosis and ageing (A. Larbi and others). MHC-unrestricted cytotoxicity in ageing (M. Provinciali, A. Donnini, R.E. Francesca). Major histocompatibility complex polymorphisms and ageing (G. Candore and others). -- III. Ageing of the endocrine system. -- Neuroplascticity in the human hypothalamus during ageing (M.A. Hofman, D.F. Swaab). The role of growth hormone signalling in the control of ageing (A. Bartke and others). Ageing and the adrenal cortex (V. Lamounier-Zepter, S.R. Bornstein). Hormonal changes in ageing men (E. Plas, S. Madersbacher, P. Berger). Ageing and the endocrine circadian system (Y. Touitou, E. Haus). Melatonin rhythms, melatonin supplementation and sleep in old age (R.F. Riemersma and others). -- IV. Ageing of the nervous system. -- Age-related changes of the human autonomic nervous system (M. Agelink, R. Malessa, D. Ziegler). Age-related alterations in autonomic nervous innervation (D.L. Bellinger, K.S. Madden, D. Lorton). Ageing and the neuroendocrine system of the gut (M. El-Salhy). Modulating effects of nutrition on brain ageing (C. Bertoni-Freddari and others). Ageing-related role of nitric oxide in the brain (S. Mariotto and others). -- V. Links between one global system and another global system during the ageing process. -- Introduction (R.H. Straub). Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: Role of zinc (E. Mocchegiani and others). Adverse lucocorticoid actions and their relevance to brain ageing (K. Dinkel, R.M. Sapolsky). Neuroendocrine immune aspects of osteoporosis during the ageing process (M. Peterlik). -- VI. The ageing process and chronic inflammatory diseases. -- Neuroendocrine immune mechanisms of accelerated ageing in patients with chronic inflammatory diseases (R.H. Straub, J. Sch̲lmerich, M. Cutolo). Thyroid autoimmunity and ageing (S. Mariotti, G. Pinna, A. Pinchera). The clinical importance of proinflammatory cytokines in elderly populations (H. Bruunsgaard, K. Krabbe). -- VII. Conclusions. -- Possible new anti-ageing strategies related to neuroendocrine immune interactions (E. Mocchegiani, R.H. Straub). Concluding remarks and future directions (I. Berczi, A. Szentivanyi).

Includes bibliographical references and index.

Description based on print version record.