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Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition.

M.S. Albert, Normal and Abnormal Memory: Aging and Alzheimer's Disease. -- S.J. Lupien and M.J. Meaney, Stress, Glucocorticoids, and Hippocampal Aging in Rat and Human. -- C.A. Barnes, Spatial Cognition and Functional Alterations of Aged Rat Hippocampus. -- A.J. Silva, K.P. Giese, and P.W. Frankland, Identification of Molecular and Cellular Mechanisms of Learning and Memory: The Impact of Gene Targeting. -- B.T. Hyman and T. Gomez-Isla, Normal Aging and Alzheimer's Disease. -- J.-P. Julien, Transgenic Mouse Models with Neurofilament-Induced Pathologies. -- P.C. Wong, D.R. Borchelt, M.K. Lee, G. Thinakaran, S.S. Sisodia, and D.L. Price, Transgenic Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease. -- G.M. Martin, Toward a Genetic Analysis of Unusually Successful Neural Aging. -- R.E. Tanzi, The Role of the Presenilins in Alzheimer's Disease. -- J.Q. Trojanowski, J.E. Galvin, M.L. Schmidt, P.-H. Tu, T. Iwatsubo, and V.M.-Y. Lee, Mechanisms of Neuron Death in Neurodegenerative Diseases of the Elderly: Role of the Lewy Body. -- S.-H. Yen, P. Nacharaju, L.-W. Ko, A. Kenessey, and W.-K. Liu, Microtubule-Associated Protein Tau: Biochemical Modifications, Degradation and Alzheimer's Disease. -- K.S. Kosik, C. Ho, U. Liyange, C. Lemere, M. Medina, and J. Zhou, A Novel Gene in the Armadillo Family Interacts with Presenilin 1. -- R. Quirion, D. Auld, U. Beffert, J. Poirier, and S. Kar, Putative Links Between Some of the Key Pathological Features of the Alzheimer's Brain. -- A. LeBlanc, Unraveling the Controversy of Human Prion Protein Diseases. -- E. Wang, Translational Control, Apoptosis, and the Aging Brain. -- H.M. Schipper, Astrocyte Senescence and the Pathogenesis of Parkinson's Disease. -- Index.

Includes bibliographical references and index.

Normal and abnormal memory: aging and Alzheimer's disease -- Stress, glucocorticoids, and hippocampal aging in rat and human -- Spatial cognition and functional alterations of aged rat hippocampus -- Identification of molecular and cellular mechanisms of learning and memory: the impact of gene targeting -- Normal aging and Alzheimer's disease -- Transgenic mouse models with neurofilament-induced pathologies -- Transgenic models of amyotrophic lateral sclerosis and Alzheimer's disease -- Toward a genetic analysis of unusually successful neural aging -- The role of the presenilins in Alzheimer's disease -- Mechanisms of neuron death in neurodegenerative diseases of the elderly: role of the Lewy body -- Microtubule-associated protein tau: biochemical modifications, degradation, and Alzheimer's disease -- A novel gene in the armadillo family interacts with presenilin 1 -- Putative links between some of the key pathological features of the Alzheimer's brain -- Unraveling the controversy of human prion protein diseases -- Translational control, apoptosis, and the aging brain -- Astrocyte senescence and the pathogenesis of Parkinson's disease.

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