Bibliothèque de L'IMIST/CNRST

Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments. Key Features * Comprehensive text, covering all aspects of the field of toxicology * Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects * Identifies the various classes of chemical compounds responsible for the toxic effects * Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention * Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables.

H. Marquardt and S. Schäfer, Foreword. Fundamentals: -- D. Milles, History of Toxicology. -- L. Hothorn and G. Hajian, Biostatistics in Toxicology. -- B. Fichtl, Toxicokinetics. -- F. Oesch and M. Arand, Xenobiotic Metabolism. -- M. Younes, Free Radicals and Reactive Oxygen Species. -- D. Brusick, Genetic Toxicology. -- H. Marquardt, Chemical Carcinogenesis. -- R. Schulte-Hermann, B. Marian, and W. Bursch, Tumor Promotion. -- K. Tindall and R. Tennant, Transgenic Rodent Models. -- J.-A. Gustafsson and C. Corton, Receptor Biology and Pathobiology. -- D. Polka, Mechanisms of Toxicity: Programmed Cell Death (Apoptosis). -- J.P. Groton, P.J. van Bladeren, F.R. Cassee, C. De Rosa, and V. Feron, Mixtures. -- Organtoxicity: -- R. Kahl, The Liver. -- C. Cojocel and E. Lock, The Kidney. -- H. Muhle and R. McClellan, Respiratory Tract. -- P. Eyer and R. Klimmek, Blood and Blood Forming Organs. -- D. Neubert, Immune System. -- J. Riviere and N. Montiero-Riviere, Skin Toxicology. -- R. Pfeiffer, Eye. -- D. Ray and K. Andreas, Nervous System. -- D. Neubert and F. Welsch, Reproduction and Development. -- J. Thomas and M. Thomas, Endocrine System-Adrenal Cortex Thyroid and Pancreas. -- K. Schümann, B. Elsenhans, and E. Richter, Gastrointestinal Tract. -- P. Boor, Cardiovascular Toxicology. -- Toxicology of Compounds: -- G. Koss and I. Tesseraux, Hydrocarbons. -- H. Bolt and J. Borlak, Halogenated Hydrocarbons. -- S. Magda, Flurohydrocarbons. -- E. Rose, E. Hodgson, and M. Roe, Pesticides. -- G. Koss and D. Wolfe, Dioxin and Dioxin-like Polychlorinated Hydrocarbons and Biphenyls. -- E. Richter and G. Sabbioni, Aromatic Amines, Nitroarenes and Heterocyclic Aromatic Amines. -- W. Köhl and G. Eisenbrand, N-Nitroso Compounds. -- S. Schäferwq, B. Elsenhans, R.L.F. Dawes, K. Schumann, and W. Forth, Metals. -- P. Eyer, Gases. -- D. Warheit, T. Hesterberg, and G. Hart, Fiber Toxicology. -- L. Szinicz and S. Baskin, Chemical and Biological Agents. -- D. Hoffmann and E. Wynder, Active and Passive Smoking. -- J. Corbett, W. Dressler, and R. Sharma, Cosmetics. -- E. Löser and G. Stropp, Polymers. -- U. Hagen, R.J. Preston, R. Fry, and J. Kummermehr, Radiation. -- J. Westendorf, The Toxicology of Natural Compounds. -- H. Bigalke and H. Wellhoner, Bacterial Toxins. -- Application of Toxicology: -- H.W. Rüdiger, Biomonitoring and Occupational Medicine. -- Environmental Toxicology: -- R. Bull, Water. -- D.J. Paustenbach and T. Rodrigues, The Role of Toxicology and Risk Assessment in Environmental Remediation. -- Krekeler, Ecotoxicology. -- Hattan and A. Rulis, Food Toxicology. -- Gelbke, B. Hildebrand, and E. Kerfoot, Toxicological Evaluation Methods for the Registration of Chemicals. -- H. Spielmann, Alternatives in Toxicological Testing. -- A. Somogyi, Regulatory Toxicology. -- Risk Assessment: -- D. Neubert and R. Conolly, Possibilities and Methods of Quantitative Risk Assessment. -- S. Safe, Toxicity Equivalents and Their Use in Hazard and Risk Assessment. -- Appendix: -- I. Ollroge, Threshold Values and Recommendations. -- H. Marquardt and S. Schäfer, Addresses of Toxicology Center and Information Sources.

Includes bibliographical references and index.

pt. 1. Fundamentals. History of toxicology -- Biostatistics in toxicology -- Principles of toxicokinetics -- Xenobiotic metabolism -- Free radicals and reactive oxygen species -- Genetic toxicology -- Chemical carcinogenesis -- Tumor promotion -- Transgenic rodent models -- Receptor toxicology -- Mechanisms of toxicology : programmed cell death (apoptosis) -- Mixtures. part 2. Organ toxicity. The liver -- The kidney -- Respiratory tract -- Blood and blood-forming organs -- Immune system -- Skin -- The eye -- Nervous system -- Reproduction and development -- Endocrine system--adrenal cortex, thyroid, and pancreas -- Gastrointestinal tract -- Cardiovascular system. part 3. Toxicology of compounds. Hydrocarbons -- Halogenated hydrocarbons -- Fluorocarbons -- Pesticides -- Dioxin and dioxin-like polychlorinated hydrocarbons and biphenyls -- Aromatic amines, nitroarenes, and heterocyclic aromatic amines -- N-nitroso compounds -- Metals -- Gases -- Fibers -- Chemical and biological agents -- Active and passive smoking -- Cosmetic toxicology -- Polymers -- Radiation -- Natural compounds -- Bacterial toxins. part 4. Applications of toxicology. Biomonitoring in occupational medicine -- Water -- Risk assessment in environmental remediation -- Ecotoxicology -- Food toxicology : legal aspects -- Food : compound related aspects -- Toxicological evaluation methods for the registration of chemicals -- In vitro methods -- Regulatory toxicology. part 5. Risk assessment. Risk assessment and preventive hazard minimization -- Toxicity equivalents and their use in hazard and risk assessment.

Description based on print version record.