Bibliothèque de L'IMIST/CNRST

Preface -- Historical Background: Virus Involvement in diabetes -- Historical Background: Autoimmune Diabetes -- Genetics of Type 1 Diabetes -- Non-genetic Factors in the Pathogenesis of Type 1 daibetes -- EMC Virus in Mice -- AZ Enteroviruses in the Mouse Model of Type 1 Diabetes -- Kilham Virus in rats -- Reoviruses in Mice -- Ljungan Virus -- Virus-related Diabetes in Cattle -- Epidemiology of Viruses in Type 1 Diabetes -- Molecular Biology of Enteroviruses -- Laboratory Diagnosiws of Enterovirus Infection -- Enterovirus Immunity and the "Hygeine Hypothesis" -- Enteroviruses in Blood -- Coxsackieviruses and Insulitis -- Viruses in the Pancreas in Diabetes -- Other Possible Diabetogenic Viruses: Rotavirus -- Viruses, Diabetes and Autoimmunity: Studies of Subjects at Genetic Risk for Type 1 Diabetes -- Diabetes and Viruses in the Tropics -- Diabetes and Viruses in Australia and the Pacific -- Fulminant Diabetes in Japan -- Defining Causal Relationship: From Outbreak Workup to Clinical Trial -- The nPOD Research Organization -- Genes, Viruses and Molecular Mimicry -- Innate and Cell-mediated Immunity to Enteroviruses -- Innate Responses to Diabetes-Producing Viruses -- Virus Infection of Human Islets In Vitro -- Virus-Induced Cytokines in Human Islets -- Antibody Enhancement of Enterovirus Infection -- Speculation on Diabetes Prevention -- Viruses as Major Environmental Factors for the Induction of Diabetes -- Sumary and Perspectives -- Index.

Diabetes, in all of its forms, now constitutes a growing health concern, affecting all segments of the world’s population. There is great interest in the factors which influence its etiology and progression. Among these, a number of viruses feature prominently. Hindered by technological limitations, research into this relationship has hitherto been scarce. Recent advances, however, have opened up the field and there is a burgeoning body of literature on the subject. Unfortunately, this literature has been diffuse and often difficult to access. For the first time, this book compiles the views of many of the world’s experts in the field. It addresses questions, ranging from how viruses may destroy or modify the function of pancreatic islets; to which viruses are the most likely culprits; to whether vaccines or etiologic therapies might be used to prevent virus-induced diabetes. Diabetes and Viruses is the first comprehensive volume on an important and expanding field of research that is of interest to clinicians, healthcare managers, epidemiologists, veterinarians, and basic scientists.