Bibliothèque de L'IMIST/CNRST

Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. * Explores latest topics in neural circuits and behavior research in zebrafish, drosophila, c.elegans, and mouse models * Includes methods for testing with ethical, legal, and social implications * Critically analyzes prospects future prospects.

Includes bibliographical references and index.

Machine generated contents note: 1. Introduction: Epigenetics and Cancer / Toshikazu Ushijima -- I. Introduction -- II. Basic Epigenetic Mechanisms -- Ghosts Above the Genes -- III. Epigenetic Events and Biological Phenomena -- Gene Wiring to Instruct Inheritance -- IV. Cancer Epigenome -- Zooming in on Genome-Wide Scale -- V. Epigenetics and Environmental Factors -- Where Your Genes Meet the Environment -- VI. Epigenetic Changes in Cancer -- Markers in Tracking Cancer Cells -- VII. Epigenetic Drugs on the Rise -- Waking Up Sleeping Beauty -- VIII. Epigenetics and Cancer Prevention -- Protect Your Epigenome -- IX. Epigenetics Databases and Computational Methodologies -- Resource and Toolbox for Community -- X. Closing Remarks -- References -- SECTION I BASIC EPIGENETIC MECHANISMS IN THE REGULATION OF CRITICAL CELLULAR PROCESSES -- 2. DNA Methylation and Cancer / Manel Esteller -- I. Introduction -- II. The Molecular Basis of DNA Methylation -- III. DNA Methylation Abnormalities in Cancer -- IV. DNA Methylation Markers -- V. Determining the Cancer DNA Methylome -- VI. Therapy Perspectives -- VII. Conclusions -- References -- 3. Histone Modifications and Cancer / Zdenko Herceg -- I. Introduction -- II. Chromatin Organization -- III. Histone Modifications -- IV. Role of Histone Modifications in Cellular Processes -- V. Deregulation of Histone Modifications as a Mechanism Underlying Cancer Development -- VI. Histone Modifications in Cancer as Potent Biomarkers -- VII. Conclusion and Future Directions -- References -- 4. Epigenetics and miRNAs in Human Cancer / George A. Calin -- I. Introduction -- II.miRNAs as Targets of Epigenetic Changes in Cancer -- III.epi-miRNAs: Regulators of the Epigenetic Machinery -- IV. Conclusion -- References -- 5. Interplay Between Different Epigenetic Modifications and Mechanisms / Rabih Murr -- I. Introduction -- II. Crosstalk Between Histone Modifications and Transcription -- III. Crosstalk Between Different Histone Modifications in Response to DNA Damage -- IV. Crosstalks Involving DNA Methylation and Transcription -- V. Conclusions and Perspectives -- References -- SECTION II EPIGENETIC EVENTS UNDERLYING BIOLOGICAL PHENOMENA -- 6. Genomic Imprinting Syndromes and Cancer / Eamonn Richard Maher -- I. Introduction -- II. The Importance of Biparental Contribution to the Mammalian Genome -- III. Mechanisms Involved in Genomic Imprinting -- IV. Mechanisms Leading to Disorders of Imprinting -- V. The 11p15.5 Imprinted Region -- VI. The 14q32 Imprinting Cluster -- VII.15q11-q13 Imprinted Region -- VIII. The 6q24 Imprinted Region -- IX. Global Genomic Imprinting Disorders: NLRP7 and Biparental Complete Hydatidiform Moles -- X. Summary/Conclusion -- References -- 7. Epigenetic Codes in Stem Cells and Cancer Stem Cells / Akira Watanabe -- I. Epigenetic Codes in Stem Cells -- II. Tissue-Specific Stem Cells and Cancer Stem Cells -- References -- 8. Inheritance of Epigenetic Aberrations (Constitutional Epimutations) in Cancer Susceptibility / Megan P. Hitchins -- I. Introduction -- II. Definitions -- III. Epimutation Conferring Floral Symmetry in Toadflax -- IV. Nomenclature and Origins of Epimutations in Humans -- V. Epimutation of the Mismatch Repair Genes in Cancer Susceptibility -- VI. Epimutations of Additional Cancer Genes in Cancer Susceptibility Syndromes -- VII. Constitutional Epimutations in Other Human Diseases -- VIII. Inheritance of Altered Epigenetic States in Mouse Phenotypes -- IX. Conclusions -- References -- SECTION III CANCER EPIGENOME -- 9. Cancer Epigenome / Stephan Beck -- I. Introduction -- II. Epigenome Analysis Approaches -- III. Cancer Epigenomes: Current State of Affairs -- IV. Potential Applications of Cancer Epigenomic Data for Risk Prediction, Diagnosis, Prognosis, and Therapy -- V. Head and Neck: Example of an Emerging Cancer Epigenome Project -- VI. Conclusion and Future Perspectives -- VII. Useful Links -- References -- 10. Identification of Driver and Passenger DNA Methylation in Cancer by Epigenomic Analysis / Gerd P. Pfeifer -- I. Introduction -- II. Aberrant DNA Methylation in Cancer -- Starting from Single Gene Studies -- III. Aberrant DNA Methylation in Cancer -- Genome-Wide Studies -- IV. Results from DNA Methylation Profiling -- V. Targeted Methylation of Genes Versus Methylation of Target Genes or "Passenger Methylation" Versus "Driver Methylation" -- VI. Inactivation of Important Biological Pathways by Cancer-Associated Methylation -- VII. Methylation of Noncoding RNA Promoters in Cancer -- VIII. Experiments that Could Distinguish Between "Driver Methylation" and "Passenger Methylation" in Cancer -- References -- 11. Epigenetic Drivers of Genetic Alterations / Hiromu Suzuki -- I. Introduction -- II. Genetic Instability and Cancer -- III. Epigenetic Drivers of Genetic Alterations -- IV. Concurrent Genetic and Epigenetic Alterations Associated With Cancer Cell Survival -- V. Conclusions -- References -- SECTION IV EPIGENETIC THERAPY AND EPIGENETIC DRUGS -- 12. DNA Demethylating Agents and Epigenetic Therapy of Cancer / Zdenko Herceg -- I. Introduction -- II. Epigenetic Deregulation in Cancer -- III. Epigenetic Therapies -- IV. Epigenetic Drugs -- V. Epigenetic Coupling Therapies -- VI. Concluding Remarks -- References -- 13. Histone Modification Therapy of Cancer / Saverio Minucci -- I. Introduction -- II. Histone Acetylation -- III. Histone Methylation -- IV. Perspectives -- References.