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Essentials of genomic and personalized medicine /

Mention d'édition :1st ed. Publié par : Elsevier/Academic Press, (Amsterdam ; | Boston :) Détails physiques : xx, 830 pages : color illustrations ; 29 cm ISBN :0123749344; 9780123749345. Année : 2010
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Includes bibliographical references and index.

The foundations of genomic and personalized medicine -- Section 1. Basics -- Organization, variation and expression of the human genome -- DNA sequencing for the detection of human genome variation -- Genome-wide association studies and genotyping technologies -- Copy number variation and human health -- DNA methylation analysis: providing new insight into human disease -- DNA microarrays in biological discovery and patient care -- Proteomics: the deciphering of the functional genome -- Comprehensive metabolic analysis for understanding of disease -- Section 2. Informatics -- Bioinformatic and computational analysis for genomic medicine -- Systems biology and systems medicine -- Electronic medical records in genomic medicine practice and research -- Online health information retrieval by consumers -- Section 3. Translational -- Translational genomics: from discovery to clinical practice -- Pharmacogenetics and pharmacogenomics -- Clinical implementation of translational genomics -- The role of genomics in enabling prospective health care -- Genome policy considerations for genomic medicine -- Federal regulation of genomic medicine -- Economic issues and genomic medicine -- Public health genomics.

Section 4. Clinical (cardiology) -- The genomics of hypertension -- Lipoprotein disorders -- Genomics of myocardial infarction -- Acute coronary syndromes -- Heart failure in the era of genomic medicine -- Genomic assessment of cardiac transplant rejection -- Genetics and genomics of hypertrophic cardiomyopathy -- Genetics and genomics of arrhythmias -- Genetics and genomics in the management of hemostasis and thrombosis -- Genomics of congenital heart disease -- Section 5. Clinical (oncology) -- Genomics in the management of lymphomas -- Genomics in leukemias -- Genomics in the diagnosis and management of lung cancer -- Genomics in the diagnosis and management of breast cancer -- Colorectal cancer -- Genomic evaluation and management of prostate cancer -- Genomic assessment of ovarian cancer -- Genomic evaluation of pancreatic neoplasms -- Genomic evaluation of head and neck cancer -- Genomic evaluation of brain tumors and gliomas -- Targeted therapies for cancer.

Section 6. Clinical (inflammatory disease) -- Genomics in the evaluation and management of rheumatoid arthritis -- Genomic evaluation of multiple sclerosis -- Genomic assessment of inflammatory bowel disease -- Asthma genomics -- Genomics in the evaluation and management of chronic obstructive pulmonary disease -- Genetics and genomics of interstitial lung disease -- Peptic ulcer disease -- Section 7. Clinical (metabolic disease) -- Genomics in pathogenesis of cirrhosis -- Genomic medicine and obesity -- Diabetes -- Section 8. Clinical (neurological disease) -- Genetics and genomics of dementia -- Genetics and genomics of Parkinson's disease -- Genomic considerations in ophthalmology -- Genomics in the diagnosis and management of depression -- Section 9. Clinical (infectious disease) -- Genomic approaches to the host response to pathogens -- Host genomics and bacterial infections -- Genomics in the evaluation and management of sepsis -- Genomics and the management of hepatitis.

Derived from the comprehensive two-volume set, work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, this book will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease.

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