TY  - BOOK
AU  - Donev,Rossen
TI  - Advances in protein chemistry and structural biology
T2  - Advances in protein chemistry and structural biology
SN  - 9780123812636 (electronic bk.)
AV  - QP551 .A38 2011eb
U1  - 572/.633 23
PY  - 2011///]
CY  - Kidlington, Oxford, UK, Waltham, MA
PB  - Academic Press/Elsevier
KW  - Proteins
KW  - Structure
KW  - Protein Conformation
KW  - chemistry
KW  - Disease
KW  - SCIENCE
KW  - Life Sciences
KW  - Biochemistry
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and indexes; Graphical representation and mathematical characterization of protein sequences and applications to viral proteins / Ambarnil Ghosh and Ashesh Nandy -- Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase : Molecular basis of congenital erythropoietic porphyria / Arola Fortian ... [and others] -- Role of fibrin structure in thrombosis and vascular disease / Amy L. Cilia La Corte, Helen Philippou and Robert A. S. Ariëns -- Structural, dynamic, and functional aspects of helix association in membranes: a computational view / Anton A. Polyansky, Pavel E. Volynsky, Roman G. Efremov -- Proteins move! : protein dynamics and long-range allostery in cell signaling / Zimei Bu and David J. E. Callaway -- Structural diversity of class I MHC-like molecules and its implications in binding specificities / Md. Imtaiyaz Hassan and Faizan Ahmad
N2  - Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission
UR  - http://www.sciencedirect.com/science/book/9780123812629
ER  -