TY  - BOOK
AU  - Beksac,,Meral
TI  - Bone marrow and stem cell transplantation
T2  - Methods in molecular medicine
SN  - 1588295958
U1  - 617.4410592 22
PY  - 2007///
CY  - [S.l.] 
PB  - Humana Press
KW  - Medical genetics
KW  - Surgery
KW  - Transplant surgery
KW  - Bone Marrow Transplantation - immunology
KW  - Bone Marrow Transplantation - methods
KW  - Bone Marrow Transplantation
KW  - HLA Antigens - immunology
KW  - Hematopoietic Stem Cell Transplantation - methods
KW  - Hematopoietic Stem Cells - immunology
KW  - Histocompatibility Testing
KW  - Stem cells - Transplantation
KW  - Medical
KW  - Medical / Nursing
KW  - Biochemistry
KW  - Hematology
KW  - Medical / Biochemistry
KW  - MEDICAL / Hematology
KW  - MEDICAL / Surgery / General
KW  - SCIENCE / Life Sciences / Cytology
KW  - Surgery - General
KW  - genetics
KW  - Bone marrow
KW  - Transplantation
KW  - Immunology
KW  - methods
KW  - Medicine: Textbooks & Study Guides
N1  - This volume is a compendium of cutting-edge molecular methods for the successful transplantation of hematopoietic stem cells. The availability of genetic profiles for committed and uncommitted stem cells combined with the determination of molecular steps involved in hematopoietic stem cell activation and self-renewal hold tremendous promise for future success in the clinic. Currently, stem cells can be quantified and sorted successfully, but transduction, labeling, and in vivo tracking of stem cells are difficult techniques with traditionally low efficiency levels. The contributors to this volume describe promising tools for stem cell transplant research models, such as in vivo bioluminescence imaging. Topics included in this volume are molecular profiling of hematopoietic stell cells, methods for imaging cell fates in hematopoiesis, PCR-SSP typing of HLA Class I and Class II alleles, sequence-based HLA typing, and typing minor HLA antigens. Also discussed in this volume are the roles of natural killer cells and killer inhibitor receptor polymorphisms, polymorphisms within epithelial receptors, molecular methods used for the detection of autologous graft contamination in lymphoid disorders, and the application of proteomics to posttransplantation follow-up. With the recent trend moving from gene expression to the protein expression profiles, the application of proteomics to the posttransplant follow-up of patients is becoming routine. As a result, this volume will become an invaluable source for biochemists, molecular biologists, and clinicians
ER  -