Bibliothèque de L'IMIST/CNRST

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. The first comprehensive description of animal models of epilepsy since the early 1970's Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research World expert opinions on the clinical relevance of each model.

Includes bibliographical references and index.

Cover -- Table of Contents -- Contributing Authors -- Foreword -- Preface -- CHAPTER 1: What Should Be Modeled? -- CHAPTER 2: Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy -- CHAPTER 3: Cell Culture Models for Studying Epilepsy -- CHAPTER 4: An Overview of In Vitro Seizure Models in Acute and Organotypic Slices -- CHAPTER 5: The Use of Brain Slice Cultures for the Study of Epilepsy -- CHAPTER 6: Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research -- CHAPTER 7: Thalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures -- CHAPTER 8: Studying Epilepsy in the Human Brain In Vitro -- CHAPTER 9: In Vitro Isolated Guinea Pig Brain -- CHAPTER 10: Pharmacologic Models of Generalized Absence Seizures in Rodents -- CHAPTER 11: Models of Chemically-Induced Acute Seizures -- CHAPTER 12: Electrical Stimulation-Induced Models of Seizures -- CHAPTER 13: Alcohol Withdrawal Seizures -- CHAPTER 14: Alumina Gel Injection Models of Epilepsy in Monkeys -- CHAPTER 15: Modeling Epilepsy and Seizures in Developing Zebrafish Larvae -- CHAPTER 16: Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice -- CHAPTER 17: Spontaneous Epileptic Mutations in the Mouse -- CHAPTER 18: Genetic Models of Absence Epilepsy in the Rat -- CHAPTER 19: Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology -- CHAPTER 20: Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibil -- CHAPTER 21: Inherited Epilepsy in Mongolian Gerbils -- CHAPTER 22: The Cortical Freeze Lesion Model -- CHAPTER 23: MAM and Other "Lesion" Models of Developmental Epilepsy -- CHAPTER 24: In Utero Irradiation as a Model of Cortical Dysplasia -- CHAPTER 25: Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period -- CHAPTER 26: Complex Febrile Seizures-An Experimental Model in Immature Rodents -- CHAPTER 27: Repetitive Seizures in the Immature Brain* -- CHAPTER 28: The Kindling Phenomenon -- CHAPTER 29: Kindling Kittens and Cats -- CHAPTER 30: Electrical Kindling in Developing Rats -- CHAPTER 31: Chemical Kindling -- CHAPTER 32: Kindling, Spontaneous Seizures, and the Consequences of Epilepsy: More Than a Model -- CHAPTER 33: Tetanus Toxin Model of Focal Epilepsy -- CHAPTER 34: Kainate-Induced Status Epilepticus: A Chronic Model of Acquired Epilepsy -- CHAPTER 35: The Pilocarpine Model of Seizures -- CHAPTER 36: Status Epilepticus: Electrical Stimulation Models -- CHAPTER 37: Posttraumatic Epilepsy Induced by Lateral Fluid-Percussion Brain Injury in Rats -- CHAPTER 38: Chronic Partial Cortical Isolation -- CHAPTER 39: Head Trauma: Hemorrhage-Iron Deposition -- CHAPTER 40: Stroke -- CHAPTER 41: Models Available for Infection-Induced Seizures -- CHAPTER 42: Brain Tumor and Epilepsy: A New Neurophysiologic and Neuropathologic Ex Vivo In Vitro Model -- CHAPTER 43: An Animal Model of Rasmussen's Encephalitis -- CHAPTER 44: Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepil.

Description based on print version record.