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Analyzing microarray gene expression data par McLachlan, Geoffrey J. Publication : New York Wiley-Interscience 2004 . 368 p. , A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis of data derived from the latest DNA microarray technologies. Designed for biostatisticians entering the field of microarray analysis as well as biologists seeking to more effectively analyze their own experimental data, the text features a unique interdisciplinary approach and a combined academic and practical perspective that offers readers the most complete and applied coverage of the subject matter to date. Following a basic overview of the biological and technical principles behind microarray experimentation, the text provides a look at some of the most effective tools and procedures for achieving optimum reliability and reproducibility of research results, including: An in-depth account of the detection of genes that are differentially expressed across a number of classes of tissues Extensive coverage of both cluster analysis and discriminant analysis of microarray data and the growing applications of both methodologies A model-based approach to cluster analysis, with emphasis on the use of the EMMIX-GENE procedure for the clustering of tissue samples The latest data cleaning and normalization procedures The uses of microarray expression data for providing important prognostic information on the outcome of disease. 24 cm. Date : 2004 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

Biostatistics a bayesian introduction par Woodworth,, George G. Publication : [S.l.] Wiley-Interscience 2004 . 384 p. , An essential introductory text linking traditional biostatistics with bayesian methods In recent years, Bayesian methods have seen an explosion of interest, with applications in fields including biochemistry, ecology, medicine, oncology, pharmacology, and public health. As an interpretive system integrating data with observation, the Bayesian approach provides a nuanced yet mathematically rigorous means of conceptualizing biomedical statistics--from diagnostic tests to DNA evidence. Biostatistics: A Bayesian Introduction offers a pioneering approach by presenting the foundations of biostatistics through the Bayesian lens. Using easily understood, classic Dutch Book thought experiments to derive subjective probability from a simple principle of rationality, the book connects statistical science with scientific reasoning. The author shows how to compute, interpret, and report Bayesian statistical analyses in practice, and illustrates how to reinterpret traditional statistical reporting--such as confidence intervals, margins of error, and one-sided p-values--in Bayesian terms. Topics covered include: * Probability and subjective probability * Distributions and descriptive statistics * Continuous probability distributions * Comparing rates and means * Linear models and statistical adjustment * Logistic regression and adjusted odds ratios * Survival analysis * Hierarchical models and meta-analysis * Decision theory and sample size determination The book includes extensive problem sets and references in each chapter, as well as complete instructions on computer analysis with the versatile SAS and WinBUGS software packages as well as the Excel spreadsheet program. For professionals and students, Biostatistics: A Bayesian Introduction offers an unique, real-world entry point into a remarkable alternative method of interpreting statistical data. 24 cm. Date : 2004 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

Contemporary bayesian econometrics and statistics par Geweke,, John. Publication : [S.l.] Wiley-Interscience 2005 . 320 p. , Tools to improve decision making in an imperfect world This publication provides readers with a thorough understanding of Bayesian analysis that is grounded in the theory of inference and optimal decision making. Contemporary Bayesian Econometrics and Statistics provides readers with state-of-the-art simulation methods and models that are used to solve complex real-world problems. Armed with a strong foundation in both theory and practical problem-solving tools, readers discover how to optimize decision making when faced with problems that involve limited or imperfect data. The book begins by examining the theoretical and mathematical foundations of Bayesian statistics to help readers understand how and why it is used in problem solving. The author then describes how modern simulation methods make Bayesian approaches practical using widely available mathematical applications software. In addition, the author details how models can be applied to specific problems, including: * Linear models and policy choices * Modeling with latent variables and missing data * Time series models and prediction * Comparison and evaluation of models The publication has been developed and fine- tuned through a decade of classroom experience, and readers will find the author's approach very engaging and accessible. There are nearly 200 examples and exercises to help readers see how effective use of Bayesian statistics enables them to make optimal decisions. MATLAB? and R computer programs are integrated throughout the book. An accompanying Web site provides readers with computer code for many examples and datasets. This publication is tailored for research professionals who use econometrics and similar statistical methods in their work. With its emphasis on practical problem solving and extensive use of examples and exercises, this is also an excellent textbook for graduate-level students in a broad range of fields, including economics, statistics, the social sciences, business, and public policy. 24 cm. Date : 2005 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Juridiques, Economiques et de Gestion (1),

Discrete multivariate distributions par Johnson,, Norman L. Publication : [S.l.] Wiley-Interscience 1997 . 328 p. , Timely, comprehensive, practical--an important working resource for all who use this critical statistical method Discrete Multivariate Distributions is the only comprehensive, single-source reference for this increasingly important statistical subdiscipline. It covers all significant advances that have occurred in the field over the past quarter century in the theory, methodology, computational procedures, and applications of discrete multivariate distributions in a wide range of disciplines. Distributions covered include multinomial, binomial, negative binomial, Poisson, power series, hypergeometric, Polya-Eggenberger, Ewens, orders, and some families of distributions. Each distribution is presented in its own chapter, along with necessary details and descriptions of real-world applications gleaned from the current literature on discrete multivariate distributions. Discrete Multivariate Distributions is the fourth volume of the ongoing revision of Johnson and Kotz's acclaimed Distributions in Statistics--universally acknowledged to be the definitive work on statistical distributions. Originally planned as a revision of Chapter 11 of that classic, this project soon blossomed into a substantial volume as a result of the unprecedented growth that has occurred in the literature on discrete multivariate distributions and their applications over the past quarter century. The only comprehensive, single-volume work on the subject, this valuable reference affords statisticians direct access to all of the latest developments concerning discrete multivariate distributions. Concentrating primarily on areas of interest to theoretical as well as applied statisticians, the authors provide complete coverage of several important discrete multivariate distributions. These include multinomial, binomial, negative binomial, Poisson, power series, hypergeometric, Polya-Eggenberger, Ewens, orders, and some families of distributions. Discrete Multivariate Distributions begins with a general overview of the multivariate method in which the authors lay the basic theoretical groundwork for the discussions that follow. For clarity and consistency, subsequent chapters follow a similar format, beginning with a concise historical account followed by a discussion of properties and characteristics. Coverage then advances to in-depth explorations of inferential issues and applications, liberally supplemented with helpful details and a collection of real-world applications obtained from the authors' extensive searches of current literature worldwide. Discrete Multivariate Distributions is an essential working resource for researchers, professionals, practitioners, and graduate students in statistics, mathematics, computer science, engineering, medicine, and the biological sciences. 24 cm. Date : 1997 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

Image processing and jump regression analysis par Qiu, Peihua. Publication : [New jersey] Wiley-Interscience 2005 . 344 p. , The first text to bridge the gap between image processing and jump regression analysis Recent statistical tools developed to estimate jump curves and surfaces have broad applications, specifically in the area of image processing. Often, significant differences in technical terminologies make communication between the disciplines of image processing and jump regression analysis difficult. In easy-to-understand language, Image Processing and Jump Regression Analysis builds a bridge between the worlds of computer graphics and statistics by addressing both the connections and the differences between these two disciplines. The author provides a systematic analysis of the methodology behind nonparametric jump regression analysis by outlining procedures that are easy to use, simple to compute, and have proven statistical theory behind them. Key topics include: Conventional smoothing procedures Estimation of jump regression curves Estimation of jump location curves of regression surfaces Jump-preserving surface reconstruction based on local smoothing Edge detection in image processing Edge-preserving image restoration With mathematical proofs kept to a minimum, this book is uniquely accessible to a broad readership. It may be used as a primary text in nonparametric regression analysis and image processing as well as a reference guide for academicians and industry professionals focused on image processing or curve/surface estimation. 24 cm. Date : 2005 Disponibilité : Exemplaires disponibles: La bibliothèque des sciences de l'ingénieur (1),

Longitudinal data analysis par Hedeker,, Donald. Publication : [S.l.] Wiley-Interscience 2006 . 360 p. , Longitudinal data analysis for biomedical and behavioral sciences This innovative book sets forth and describes methods for the analysis of longitudinaldata, emphasizing applications to problems in the biomedical and behavioral sciences. Reflecting the growing importance and use of longitudinal data across many areas of research, the text is designed to help users of statistics better analyze and understand this type of data. Much of the material from the book grew out of a course taught by Dr. Hedeker on longitudinal data analysis. The material is, therefore, thoroughly classroom tested and includes a number of features designed to help readers better understand and apply the material. Statistical procedures featured within the text include: * Repeated measures analysis of variance * Multivariate analysis of variance for repeated measures * Random-effects regression models (RRM) * Covariance-pattern models * Generalized-estimating equations (GEE) models * Generalizations of RRM and GEE for categorical outcomes Practical in their approach, the authors emphasize the applications of the methods, using real-world examples for illustration. Some syntax examples are provided, although the authors do not generally focus on software in this book. Several datasets and computer syntax examples are posted on this title's companion Web site. The authors intend to keep the syntax examples current as new versions of the software programs emerge. This text is designed for both undergraduate and graduate courses in longitudinal data analysis. Instructors can take advantage of overheads and additional course materials available online for adopters. Applied statisticians in biomedicine and the social sciences can also use the book as a convenient reference. 25 cm. Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

Markov decision processes discrete stochastic dynamic programming par Puterman, Martin L. Publication : [S.l.] Wiley-Interscience 2005 . 684 p. , The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. "This text is unique in bringing together so many results hitherto found only in part in other texts and papers. . . . The text is fairly self-contained, inclusive of some basic mathematical results needed, and provides a rich diet of examples, applications, and exercises. The bibliographical material at the end of each chapter is excellent, not only from a historical perspective, but because it is valuable for researchers in acquiring a good perspective of the MDP research potential." -Zentralblatt fur Mathematik ". . . it is of great value to advanced-level students, researchers, and professional practitioners of this field to have now a complete volume (with more than 600 pages) devoted to this topic. . . . Markov Decision Processes: Discrete Stochastic Dynamic Programming represents an up-to-date, unified, and rigorous treatment of theoretical and computational aspects of discrete-time Markov decision processes." -Journal of the American Statistical Association. 24 cm. Date : 2005 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

Nonparametric regression methods for longitudinal data analysis : mixed-effects modeling approaches par Wu, Hulin. Publication : [S.l.] Wiley-Interscience 2006 . 400 p. , Incorporates mixed-effects modeling techniques for more powerful and efficient methods This book presents current and effective nonparametric regression techniques for longitudinal data analysis and systematically investigates the incorporation of mixed-effects modeling techniques into various nonparametric regression models. The authors emphasize modeling ideas and inference methodologies, although some theoretical results for the justification of the proposed methods are presented. With its logical structure and organization, beginning with basic principles, the text develops the foundation needed to master advanced principles and applications. Following a brief overview, data examples from biomedical research studies are presented and point to the need for nonparametric regression analysis approaches. Next, the authors review mixed-effects models and nonparametric regression models, which are the two key building blocks of the proposed modeling techniques. The core section of the book consists of four chapters dedicated to the major nonparametric regression methods: local polynomial, regression spline, smoothing spline, and penalized spline. The next two chapters extend these modeling techniques to semiparametric and time varying coefficient models for longitudinal data analysis. The final chapter examines discrete longitudinal data modeling and analysis. Each chapter concludes with a summary that highlights key points and also provides bibliographic notes that point to additional sources for further study. Examples of data analysis from biomedical research are used to illustrate the methodologies contained throughout the book. Technical proofs are presented in separate appendices. With its focus on solving problems, this is an excellent textbook for upper-level undergraduate and graduate courses in longitudinal data analysis. It is also recommended as a reference for biostatisticians and other theoretical and applied research statisticians with an interest in longitudinal data analysis. Not only do readers gain an understanding of the principles of various nonparametric regression methods, but they also gain a practical understanding of how to use the methods to tackle real-world problems. 24 cm. Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

Discriminant analysis and statistical pattern recognition / par McLachlan, Geoffrey J., Publication : Hoboken, N.J. : Wiley-Interscience, 2004 . xv, 526 pages : 23 cm. Date : 2004 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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