Bibliothèque de L'IMIST/CNRST

Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney. Key Features * Hundreds of color figures depicting key events in all aspects of kidney development * Full coverage of the genetic and cellular basis of kidney development * Analysis of the genetic basis of the major congenital kidney diseases.

Foreword -- SECTION 1: EMBRYONIC KIDNEYS AND MODELS -- 1. Introduction: the embryonic kidneys and other nephrogenic models -- 2. Development of the Malpighian tubules in Drosophila melanogaster -- 3. Induction, development and physiology of the pronephric tubules -- 4. Formation of the nephric duct -- 5. The pronephric glomus and vasculature -- 6. Development of the mesonephric kidney -- 7. 3-Dimensional anatomy of mammalian mesonephroi -- 8. The Molecular control of pronephros development- an Overview -- 9. Embryological, genetic and molecular tools for investigating embryonic kidney development -- SECTION 2: THE ADULT KIDNEYS -- 10. Introduction -- 11. Anatomy and Histology of the Human Urinary System -- 12. Development of the Ureteric Bud -- 13. The Fates of the Metanephric Mesenchyme -- 14. The Formation and Development of Nephrons -- 15. Establishment of polarity in epithelial cells of the developing nephron -- 16. Development of the Glomerular Capillary and its Basement Membrane -- 17. The development of kidney blood vessels -- 18. The Development of function in the metanephric kidney -- 19. Experimental methods for studying urogenital development -- 20. Overview: The Molecular Basis of Kidney Development -- SECTION 3: CONGENITAL DISEASE -- 21. Maldevelopment of the Human Kidney and Lower Urinary Tract: an Overview -- 22. Wilms' Tumor and related disorders -- 23. Pax-2 and Renal-Coloboma Syndrome -- 24. Polycystic Kidney Disease, von Hippel Lindau and Tuberous sclerosis -- 26. Renal Cell Carcinoma: The Human Disease -- 27. The Tubule -- 28. Diseases of the Glomerular Filtration Barrier: Alport Syndrome and Congenital Nephrosis (NPHS1) -- 29. Congenital Kidney Diseases: Prospects for New Therapies.

Includes bibliographical references and index.

Description based on print version record.