Bibliothèque de L'IMIST/CNRST

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Molecular diagnostics : current technology and applications / par Rao,, Juluri R. Publication : [S.l.] : Taylor & Francis, 2006 . 400 p. ; , Molecular techniques are being harnessed for the detection of organisms in a wide range of circumstances. Global trade has introduced new pests of crops and plants; simultaneously, there is universal concern from disease outbreaks such as BSE, Foot & Mouth and the dreaded bird-flu virus. Molecular diagnostic applications for the detection of foodborne bacterial pathogens and genetically modified organisms in food are also becoming increasingly important. This book provides a critical assessment of the various molecular methods in medical and veterinary science, forensics, biodefense, plant science, food safety and quarantine sciences. Aimed at a wide range of end-users encompassing postgraduates, postdoctoral research scientists, established researchers and specialist scientists, the authors describe and evaluate molecular techniques and applications in this increasingly important area. Topics include the molecular methods for the direct detection of pathogens such as E. coli O157:H7, MRSA and other important bacterial infections, medical viruses, medical parasites, dental plaque bacteria and haematological malignancies. Also covered is the molecular recognition and detection of catastrophic bio-threat agents as a consequence of global terrorism. 24 cm. Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Nucleic acids hybridization : modern applications.   Publication : [S.l.] : Springer, 2007 . 316 p. ; , WatsonЀ“Crick hybridization of complementary sequences in nucleic acids is one of the most important processes necessary for molecular recognition in vivo, as well as nucleic acid identification and isolation. This book is devoted to a large family of in vitro DNA hybridization-based experimental techniques. A wide spectrum of experimental tasks covered by these approaches includes finding differential sequences in both genomic DNAs and mRNAs, genome walking, multiplex PCR, cDNA library construction starting from minute amount of total RNA, rapid amplification of cDNA 5Ѐ™ and 3Ѐ™ ends, effective smoothing of the concentrations of rare and abundant transcripts in cDNA libraries, recovery of promoter active repeats and differentially methylated genomic DNA, identification of common sequences in genomic or cDNA sources, new gene mapping, finding evolutionary conserved DNA and both single-nucleotide and extended mutation discovery or large-scale monitoring. Several approaches, such as microarray hybridization, have become extremely popular tools for specialists in biochemistry and in biomedicine, whereas the potential of many other advantageous techniques seems to be underestimated now. The international team of the authors of this book has tried both to elucidate the current state-of-art in hybridization techniques and to help the readers in choosing an appropriate method for performing an experiment in the most efficient way. Enclosed experimental protocols along with both comprehensive and detailed method descriptions make this truly universal book useful to all those interested in the modern life science methodologies. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Peroxiredoxin systems : structures and functions / par Flohé,, Leopold. Publication : [S.l.] : Springer, 2007 . 410 p. ; , The peroxiredoxins represent an important emerging family of sulfhydryl-linked antioxidant proteins, apparently ubiquitously present in all known organisms. The antioxidant function of the peroxiredoxins complements that of other enzymic and non-enzymic systems within the cell. In addition, there is increasing evidence that the peroxiredoxins play a role in cell signalling, by controlling and/or sensing hydrogen peroxide and peroxynitrite levels. In this, the first book containing a broad survey on the peroxiredoxins, the editors succeeded to involve almost all groups that contributed significant insights into the emerging field. The diverse biological roles of the new protein family are discussed in the context of other antioxidant systems like those based on heme or selenium catalysis. Finally, related future perspectives, which range from antimicrobial therapy up to the understanding of human development and carcinogenesis, are highlighted. Specifically, the book will be of outstanding interest to researchers who want to understand how micro-organisms, plants and animals cope with oxidative stress and how such stress is recognized and linked to adaptive responses via redox regulation of cellular processes. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Single molecule chemistry and physics : an introduction / par Wang,, Chen. Publication : [S.l.] : Springer, 2006 . 303 p. ; , The characterization of individual molecules has been a scientifically attractive and challenging task for decades, and remains so today. New technological developments have facilitated great progress in our understanding of the structure and behavior of single atoms and molecules in various environments. This book provides an introduction to the most important experimental and theoretical methods for characterizing and imaging single molecules, including scanning tunnelling and atomic force microscopy of molecules at surfaces, fluorescence studies, near-field optical microscopy and Raman spectroscopy. It also elucidates newly discovered properties of single-molecular systems and their relevance to the fast growing field of nanotechnology. 24 cm. Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Therapeutic neovascularization quo vadis?   Publication : [S.l.] : Springer, 2007 . 262 p. ; , The volume "Therapeutic Neovascularization: Quo Vadis?" picks up the current refinements in fundamental concept of neovascularization, which in the future might pave the way towards a new era of therapeutic applications. It meets an at times urgent need for treatment of patients who otherwise are not suitable for the established routines of percutaneous and surgical revascularization. At present most of the clinical trials initiated to promote neovascularization of ischemic myocardial or peripheral muscle tissue have failed to provide significant improvement of prespecified endpoints. This collection of manuscripts is selected to provide the most recent developments improving the auspices of successful revascularization therapy. Therefore, it covers sections such as the clinical challenge, novel mechanical and molecular concepts and cell therapy as an option, each composed of chapters written by experts in their fields. This collection of current and future concepts of neovascularization offers fascinating insights into refining a powerful therapeutic tool which has not yet had the chance to live up to the expectations and needs of the medical community. Indeed, the scientific modifications of a fundamentally sound concept will enable its applicability in the not so distant future. The condensed collection of current views on neovascularization is intended to speed up this process. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Toxic plants dangerous to humans and animals / par Bruneton, Jean. Publication : [S.l.] : Lavoisier, 2000 . 545 p. ; , Physicians, pharmacists and veterinarians who deal with accidental plant ingestions on a daily basis are largely ill-prepared to manage such cases. Reliable information is therefore scarce. "Toxic Plants" seeks to meet this need. Part 1 lists the common causes of plant induced incidents and accidents in humans. The risks are described, in particular those inherent to herbal drugs. Plant identification and medical treatment are discussed , as well as the specifics of animal poisoning, paying special attention to pets. Part 2 is a detailed discussion of the plant species, most frequently implicated. It includes the circumstances of the intoxication, symptoms, proposed treatment, toxic doses, and also elements of diagnosis, toxin identification and toxic mechanisms. This book contains more than 1300 literature references and the most recent statistics. Four dozen botanical families are classified alphabetically with over 350 plant species including 100 plant monographs and numerous illustrations. This highly educational tool gives a complete picture of the toxic potential of higher plants. 25 cm. Date : 2000 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Fundamentals of receptor, enzyme, and transport kinetics / par Matthews, John Charles. Publication : Boca Raton : CRC Press, 1993 . 167 pages : 25 cm. Date : 1993 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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