Bibliothèque de L'IMIST/CNRST

Volume 6 of Biomembranes covers transmembrane receptors and channels. A particularly important role for the membrane is that of passing messages between a cell and its environment. Part I of this volume covers receptors for hormones and growth factors. Here, as in so many other areas of cell biology, the application of the methods of molecular biology have led to the recognition of a number of families of receptors. Typically, such receptors contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular catalytic domain whose activation, as a result of ligand binding, leads to generation of second messengers within the cell and stimulation of a range of cytosolic enzymes. An alternative signaling strategy, exploited in particular in the nervous system, is to use ion channels to allow controlled movement of monovalent (Na<SUP>+</SUP>, K<SUP>+</SUP>) or divalent (Ca<SUP>2+</SUP>) cations in or out of the cell, resulting in changes in membrane potential or alterations in the intracellular concentration of Ca<SUP>2+</SUP>. Part II of this volume is concerned with these ion channels and with other, often simpler, ion channel systems whose study can throw light on channel mechanism.

Includes bibliographical references and index.

part 1. Receptors for hormones and growth factors: Insulin receptor signaling / Chin K. Sung and Ira D. Goldfine. Growth factor receptor tyrosine kinases / Michael J. Fry. Transmembrane protein tyrosine phosphatases / Edward C.C. Wong, Terry A. Woodford-Thomas, and Matthew L. Thomas. Regulation of the mammalian adenylyl cyclases / Roy J. Duhe, Andrew H. Dittman, Zhiliang Wu, and Daniel R. Storm. The prolactin/growth hormone/cytokine receptor superfamily / P.A. Kelly, J. Finidori, M. Edery, and M.C. Postel-Vinay. Interleukin-1 receptors / Steven K. Dower and John E. Sims. Nerve growth factor receptors / Ralph A. Bradshaw and Hubert Hondermarck.

part 2. Channels: Voltage-gated potassium channels / Olaf Pongs. Voltage-gated calcium channels / Gabor Mikala, John L. Mershon, and Arnold Schwartz. Cyclic nucleotide-gated channels / Paulus W. Wohlfart and Neil J. Cook. IP3-sensitive calcium channel / Katsuhiko Mikoshiba, Teiichi Furuichi, and Atsushi Miyawaki. The ryanodine receptor / A.G. Lee. The dynamic nature of gramicidin / Declan A. Doyle and B.A. Wallace. The MIP family of integral membrane channel proteins / Milton H. Saier, Aiala Reizer, and Jonathan Reizer. Ion channels of mitochondrial membranes / Carmen A. Mannella and Kathleen W. Kinnally. Index.

Description based on print version record.