Bibliothèque de L'IMIST/CNRST

Cell and Molecular Responses to Stress is a new multi-volume book series from Elsevier Science that focuses on how organisms respond at a molecular level to environmental stresses imposed upon them. All organisms deal with variations in multiple environmental factors including temperature, oxygen, salinity, and water availability. Many show amazing tolerances to extreme stress with remarkable biochemical adaptations that allow life to persist under very difficult circumstances. This series explores the molecular mechanisms by which cells and organisms respond to stress, focusing on the variations in metabolic response that allow some cells and organisms to deal with extreme stress, others to endure stress within strict limits, and others to have a very low tolerance for changes in environmental parameters. Articles from within the series highlight the elastic limits of molecular responses in Nature, with examples drawn from animal, plant and bacteria systems. Volume 1, begins by considering some of the roles of environmental stress in determining the geographic distribution of animals and in promoting species divergence and then explores gene expression and metabolic responses to environmental stress with examples of adaptation to high and low temperature, osmotic, anoxia/ischemia, desiccation, high pressure and heavy metal stresses.

Includes bibliographical references and index.

Cover -- Contents -- Preface -- List of contributors -- Chapter 1. Cell Homeostasis and Stress at Year 2000-Two Solitudes and Two Research Approaches -- 1. Introduction -- 2. Contrasting demands of homeostasis and tissue work -- 3. Two categories of models of metabolic regulation -- 4. High precision: the key feature of metabolic pathway integration -- 5. Regulation of human muscle metabolism during work . -- 6. Stability of [metabolites] during changes in tissue work is a general rule -- 7. Traditional explanations of the [s] stability paradox -- 8. Oxygen delivery is fundamental to metabolic regulation -- 9. Oxygen signal transduction in working muscle -- 10. Framework II: explaining the [s] stability paradox with intracellular structure and intracellular perfusion systems -- 11. Summary -- Acknowledgements -- References -- Chapter 2. Quantitative design of muscle energy metabolism for steady-state work -- 1. Introduction -- 2. Steady-state muscle work and ATP utilization -- 3. Pathways of ATP synthesis in muscles -- 4. Biochemical capacities and physiological loads -- 5. Regulating rates to match prevailing requirements -- 6. Upper limits to design and performance -- 7. Conclusion -- Acknowledgements -- References -- Chapter 3. Adaptation and Divergence in Stressful Environments -- 1. Introduction -- 2. Nutrient stress -- 3. Thermal stress -- 4. Conclusions -- Acknowledgements -- References -- Chapter 4. Stress and the Geographic Distribution of Marine and Terrestrial Animals -- 1. Introduction -- 2. Limits to geographic ranges: physiological implications -- 3. The evidence for physiological range limitation -- 4. Stress and species borders: lessons and lacunae -- 5. Rapoport's "rule": the physiological assumptions of macroecology -- 6. Prospects for future analyses -- Acknowledgements -- References -- Chapter 5. The Evolution of Thermal Sensitivity in Changing Environments -- 1. Introduction -- 2. The model -- 3. Results -- 4. Discussion -- 5. Conclusions -- Acknowledgements -- References -- Chapter 6. Adaptations of the Cell Membrane for Life in Extreme Environments -- 1. Introduction -- 2. Bioenergetics of extremophiles -- 3. Summary -- Acknowledgements -- References -- Chapter 7. Cell and Molecular Responses to Hypoxic Stress -- 1. Introduction -- 2. The HIF Story: a model switch mechanism -- 3. Study of hypoxia and cell survival: novel approaches -- 4. Genetic Model Systems -- References -- Chapter 8. Molecular and Cellular Stress Pathways In Ischemic Heart Disease: Targets for Regulated Gene Therapy- Keith A. Webster -- 1. Introduction -- 2. Coronary artery disease -- 3. Bioenergetics and biochemistry of ischemia -- 4. Conventional therapy for ischemia and congestive heart failure -- 5. Redox stress in ischemia reperfusion -- 6. Stress- and mitogen-activated protein kinases -- 7. Apoptosis and heart disease -- 8. IGF-1, PI(3)K and apoptosis -- 9. Gene therapy for myocardial dysfunction -- 10. Summary -- Acknowledgement -- Refer.

Description based on print version record.