Stereoselective Syntheses of Tetrahydropyrans Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A /
Collection : Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053 Détails physiques : XIX, 184 p. 256 illus., 12 illus. in color. online resource. ISBN :9783319044620.Introduction -- Significance -- General Approaches to the Synthesis of Substituted Tetrahydropyrans -- Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Addition Reactions -- Introduction -- Preliminary Study -- Result and Discussion -- Synthesis of 4-Hydroxy-2,6-cis-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2′ Reaction.
In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)-diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology. .
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