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Fundamentals of PAP test cytology par Hoda, Rana S. Publication : Totowa, N.J. Humana Press 2007 . xiv, 238 p. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Guide to signal pathways in immune cells par Wardle,, E. Nigel. Publication : [S.l.] Humana Press 2009 . 415 p. , In Guide to Signal Pathways in Immune Cells, Nigel E. Wardle presents vital information in regards to white cells, like the neutrophils and macrophages, T and B lymphocytes, natural killer cells and mast cells, as they constitute the immune defenses against microbial invaders or tumor cells. In all such cells the necessary information processing for their activities utilizes a network of intracellular signaling pathways. As a guide this book aims to extend understanding of the basic signal transduction pathways that will be suitable for students of immunology or cell biology and for medical personnel at all levels. 24 cm. Date : 2009 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Molecular evolution : a phylogenetic approach / par Page,, Roderick D.M. Publication : [S.l.] : Wiley-Blackwell, 1998 . 352 p. ; , The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility. 25 cm. Date : 1998 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Neuroendocrine cells and peptidergic innervation in human and rat prostrate / par Santamaría,, Luis. Publication : [S.l.] : Springer, 2007 . 80 p. ; , The prostate hosts an important amount of neuroendocrine cells which origin and functional role need to be better addressed. These cells synthesize and deliver a number of neurosecretory substances (serotonin, neuropeptides) having regulative activities over growth, cell differentiation, and secretion and might have a remarkable influence in the development of prostatic proliferative disorders such as hyperplasia or cancer. Moreover, the autonomous nervous system seems to be relevant in the maintenance of structural and functional integrity of the prostate, a wide variety of peptidergic fibres has been described in the prostate gland; such as neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP) nerves, etc. There is evidence about morphologic and functional relationships between neuroendocrine cells and prostate nerve fibres, resulting in a neuro-hormonal system that might modulate the androgenic action on the prostate. Using immunohistochemistry and stereologic quantification, the authors of the present study deal with the demonstration that the neuroendocrine cells population from transition zone of the human prostate was greater than in both central and peripheral regions, and this can be put in relation to the genesis of BPH. Furthermore, they observed that the neuroendocrine cells and the peptidergic innervation of rat prostate might be influenced by aging and androgenic status. Other factors, as pharmacological castration, or prolactin action, might be also modulate the neuroendocrine-peptidergic system. 23 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Peroxiredoxin systems : structures and functions / par Flohé,, Leopold. Publication : [S.l.] : Springer, 2007 . 410 p. ; , The peroxiredoxins represent an important emerging family of sulfhydryl-linked antioxidant proteins, apparently ubiquitously present in all known organisms. The antioxidant function of the peroxiredoxins complements that of other enzymic and non-enzymic systems within the cell. In addition, there is increasing evidence that the peroxiredoxins play a role in cell signalling, by controlling and/or sensing hydrogen peroxide and peroxynitrite levels. In this, the first book containing a broad survey on the peroxiredoxins, the editors succeeded to involve almost all groups that contributed significant insights into the emerging field. The diverse biological roles of the new protein family are discussed in the context of other antioxidant systems like those based on heme or selenium catalysis. Finally, related future perspectives, which range from antimicrobial therapy up to the understanding of human development and carcinogenesis, are highlighted. Specifically, the book will be of outstanding interest to researchers who want to understand how micro-organisms, plants and animals cope with oxidative stress and how such stress is recognized and linked to adaptive responses via redox regulation of cellular processes. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Serial analysis of gene expression.   Publication : [S.l.] : Humana Press, 2007 . 208 p. ; , Serial Analysis of Gene Expression (SAGE): Digital Gene Expression Profiling facilitates the introduction of SAGE into the laboratory, and provides a framework for interpreting and comparing data derived from SAGE experiments. Of the several methods of genetic profiling available, only SAGE measures the expression of both known and unknown genes. SAGE studies encompass 50,000 tags and can provide detailed knowledge of the 2000 most highly expressed genes in the tissue sample. The SAGE protocols presented are detailed, fully annotated, and tested, and are all written by experienced SAGE researchers from around the world. Part 1 is dedicated to experimental procedures of SAGE and related methods including aRNA LongSAGE, SuperSAGE, DeepSAGE, and GMAT. Part 2 provides methods for extraction and filtration of tags, analysis of ditag populations, and completing statistically correct comparisons of gene expression profiles. Comparative transcriptomics enables scientists to understand the underlying genetics of biological changes such as development, disease, crop yield, and resistance. SAGE analysis is also used to obtain unknown tags, which can be used as gene-specific primers in Rapid Amplification of cDNA Ends (RACE) reactions to generate full-length transcripts for cloning and sequencing. This book will be an indispensable tool for any lab engaged in genetic profiling and comparative transcriptomics, and will help many laboratories to successfully implement tag-based sequencing methods and procedures and obtain comprehensive, useful, and interpretative data. 23 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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