Bibliothèque de L'IMIST/CNRST

This book provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. * Contributions from leading international authorities in the field * Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system * Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator.

Perspective on Immunological mechanisms underlying adjuvant activity -- Host-derived immunopotentiators -- Natural and synthetic immunopotentiators -- Particulate immunopotentiators and delivery systems -- Mucosal/ non-parenteral adjuvants -- Th-1/ CTL adjuvants -- Adjuvants in non-infectious disease vaccines -- Clinical Practice.

Includes bibliographical references and index.

Unravelling "the immunologist's dirty little secret" / Virgil E.J.C. Schijns -- Dendritic cells as targets and tools in vaccines / Imerio Capone, Paola Rizza, and Filippo Belardelli -- Host-derived molecules as adjuvants / Tom Barr, Jennifer Carlring, and Andrew W. Heath -- Innate immune mechanisms and the identification of immune potentiators as vaccine adjuvants / Achal Pashine, Jeffrey B. Ulmer, and Nicholas M. Valiante -- CpG oligodeoxynucleotides as vaccine adjuvants / Michael J. McCluskie and Risini D. Weeratna -- Toll-like receptor 4 agonists as vaccine adjuvants / David H. Persing ... [and others] -- Immunomodulatory adjuvants from Quillaja saponaria / Charlotte Read Kensil.

Microparticles as vaccine delivery systems / Derek T. O'Hagan -- MF59: a safe and potent adjuvant for human use / Audino Podda, Giuseppe Del Giudice, and Derek T. O'Hagan -- Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminium salt / Nathalie Garçon, Marcelle van Mechelen, and Martine Wettendorff -- Virosomes for vaccine delivery / Ian C. Metcalfe and Reinhard Glück -- The ISCOMATRIX adjuvant / Debbie Drane and Martin J. Pearse -- Mineral adjuvants / Erik B. Lindblad.

Mucosal adjuvants based on cholera toxin and E. coli heat-labile enterotoxin / Jan Holmgren ... [and others] -- Transcutaneous immunization using the heat-labile enterotoxin of E. coli as an adjuvant / Richard T. Kenney and Gregory M. Glenn -- T cell adjuvants and novel strategies for their identification / Laurence Van Overvelt and Philippe Moingeon -- Vaccination to treat noninfectious diseases: surveying the opportunities / Stephen W. Martin and Martin F. Bachmann -- Clinical evaluation of adjuvants / Jakub K. Simon and Robert Edelman -- Regulatory considerations in the nonclinical safety assessment of adjuvanted preventive vaccines / Elizabeth M. Sutkowski and Marion F. Gruber.

Description based on print version record.