Bibliothèque de L'IMIST/CNRST

ReferencesChapter 4 - Computational Approaches; Introduction; Challenges in Modeling Nanoparticle Biological Effects; Examples of Nanotoxicology Modeling Approaches; Quantum Chemical Studies of Toxicity of Nanoparticles; Statistical Modeling and Machine Learning Methods; Nanotoxicological Fingerprints to Classify Nanomaterials; Molecular Modeling and Molecular Dynamics Methods; Elucidating Interactions Between Nanomaterials and Proteins; Other Modeling Approaches for Nanotoxicology; Conclusions; Take-Home Messages; References; Chapter 5 - Exposure Assessment; Background

Section A -- Engineered nanomaterials: hazard, exposure, risk assessment; Chapter 1 -- Bio-Nano Interactions; Introduction; Protein Corona on Nanoparticles; Development of the Protein Corona; Hard Corona Versus Soft Corona; The Biomolecule Corona Composition; Dynamic Formation of the Biocorona; Impact of the NP-Biomolecule Corona on Human Systems; In Vitro Studies; In Vivo Studies; Microbiome Interactions; Nanotoxicity and the Biomolecule Corona; Conclusions; Take-Home Messages; Acknowledgments; References

Chapter 2 -- Physicochemical CharacterizationIntroduction; Overview of Key Physicochemical Parameters; Modalities of Physicochemical Characterization; Particle Size, Size Distribution, Agglomeration, and Aggregation; Shape; Specific Surface Area and Porosity; Chemical Composition, Purity, and Crystal Structure (Crystallinity); Surface Chemistry (and Contamination); Surface Charge Density and Stability in Dispersion; Dispersibility and Solubility; Dustiness; Sample Preparation and Dispersion Media; Data Collection and Interpretation; Take-Home Messages; Acknowledgments; Disclaimer; References

Chapter 3 -- Toxicity Tests: In Vitro and In VivoIntroduction; Methods for Visualizing Cellular Uptake and Biodistribution; Evaluation of Transport and Uptake of ENM In Vitro and In Vivo; In Vitro Toxicity Tests; Cytotoxicity Tests; Limitations of In Vitro Tests; New In Vitro Test Principles; Validated Cytotoxicity Tests; Genotoxicity Tests; Ex Vivo Models; In Vivo Toxicity Testing; Toxicokinetics; Immunological Responses; Chronic Toxicity and Carcinogenicity; Considerations for Selection of Toxicity Tests: In Vitro/In Vivo Comparison; Conclusions; Take-Home Messages; Acknowledgments

How can Workers be Exposed to ENMs?Exposure Routes; Characterization of Behavior of ENMs; Challenges to Assess Exposure to ENMs; Exposure Assessment of ENMs in Workplaces; Evidence for Release of Engineered Nanoparticles in the Workplace; Harmful Effects on Workers; How to Measure Nanoparticles: Metrics; How to Measure Nanoparticles: Measurement Strategies; Instruments Measuring Number Concentration; Instruments Measuring Surface Concentration; Instruments Measuring Mass Concentration; Instruments Giving Indirect Estimates; Sample Collection and Characterization