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Exemplaires : http://www.sciencedirect.com/science/book/9780121020514

The Guide to Human Genome Computing is invaluable to scientists who wish to make use of the powerful computing tools now available to assist them in the field of human genome analysis. This book clearly explains access and use of sequence databases, and presents the various computer packages used to analyze DNA sequences, measure linkage analysis, compare and align DNA sequences from different genes or organisms, and infer structural and functional information about proteins from sequence data. This Second Edition contains completely updated material. Rather than a revision of the previous volume, the Second Edition is essentially a new book, based on the subjects which will be of interest over the coming years. This new book is international, both in scope and authorship. Computing resources for the following are clearly explained: * Internet resources - databases et cetera * Genetic analysis * Sib-pair studies * Comparative mapping * Radiation hybrids * Sequence ready clone maps * Human genome sequencing * ESTs * Gene prediction * Gene expression.

L. Stein, Introduction to Human Genome Computing via the World Wide Web. -- M. Rhodes and R. Elaswarapu, Biological Materials and Services. -- S. Bryant, Managing Pedigree and Genotype Data. -- P. Sham and J. Zhao, Linkage Analysis Using Affected Sib-Pairs. -- M. Bishop, Comparative Mapping in Man and Vertebrates. -- L. McCarthy and C. Soderland, Radiation Hybrid Mapping. -- C. Soderland, S. Gregory, and I. Dunham, Sequence Ready Clone Maps. -- S. Dear, Software for Human Genome Sequencing. -- G. Slater, Human EST Sequences. -- L. Milanesi and I. Rogozin, Prediction of Human Gene Structure. -- A. Krogh, Gene Finding: Putting the Parts Together. -- D. Davidson and C. Dubreuil, Gene Expression Databases.

Includes bibliographical references and index.

Introduction to human genome computing via the world wide web / Lincoln D. Stein -- Biological materials and services / Michael Rhodes, Ramnath Elaswarapu -- Managing pedigree and genotype data / Stephen P. Bryant -- Linkage analysis using affected sib-pairs / Pak Sham, Jinghua Zhao -- Comparative mapping in humans and vertebrates / Martin Bishop -- Radiation hybrid mapping / Linda McCarthy, Carol Soderlund -- Sequence ready clone maps / Carol Soderlund, Simon Gregory, Ian Dunham -- Software for human genome sequencing / Simon Dear -- Human EST sequences / Guy St C. Slater -- Prediction of human gene structure / Luciano Milanesi, Igor B. Rogozin -- Gene finding : putting the parts together / Anders Krogh -- Gene-expression databases / Duncan Davidson, Martin Ringwald, Christophe Dubreuil.

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