Bibliothèque de L'IMIST/CNRST

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Includes bibliographical references and index.

Cover -- Contents -- List of Contributors -- General Section -- Chapter 1. Anti-idiotypes as Vaccines: Theoretical Considerations -- Chapter 2. Anti-idiotypes -- Chapter 3. X-ray Crystallographic Studies of the Idiotypic Cascade -- Chapter 4. The Structure and Thermodynamics of Antibody-Protein Antigen Interactions -- Autoimmunity Section -- Chapter 5. Introduction -Idiotypes and Anti-idiotypes -- Chapter 6. Cross-Reactive Idiotypes in Human Lupus Families -- Chapter 7. Idiotypes of Anti-DNA Antibodies -- Chapter 8. Idiotypes of Anti-Sm Antibodies -- Chapter 9. Idiotypes of Anti-Ro and Anti-La -- Chapter 10. Idiotypes on Autoantibodies in Myasthenia Gravis -- Chapter 11. Idiotypes of ANCA -- Chapter 12. Ig Genes and Idiotype of Anti-Mitochondria1 Antibodies in Primary Biliary Cirrhosis -- Chapter 13. Idiotypes of Anti-Phospholipid Antibodies -- Chapter 14. Anti-Idiotypic Antibodies Against Human Insulin Autoantibodies (IAA) -- Chapter 15. Molecular and Cellular Aspects of Human Rheumatoid Factor Production and Idiotypes -- Chapter 16. Idiotypes of Anti-Thyroglobulin Antibodies -- Chapter 17. Idiotypes of Human Platelet-Specific Antibodies -- Chapter 18. Idiotypes of Platelet Associated Antibodies (Autoimmune Thrombocytopenia) -- Chapter 19. Idiotypes of Natural Autoantobodies and Monoclonal Gammopathies -- Chapter 20. Idiotypes and Anti-Idiotypes in Allergy -- Chapter 21. Anti-idiotypes to Autoantibodies in Therapeutic Preparations of Normal Polyspecific Human IgG (Intravenous Immunoglobulin, IVIg) -- Chapter 22. Manipulation of Autoantibody Idiotypes In Autoimmune Diseases -- Chapter 23. Anti-Idiotypic Monoclonal Antibody (mAb) to Anti-CD4 mAb as Surrogate of Human CD4 Antigen (Ag) for Active Immunotherapy of Autoimmune Diseases -- Infection Section -- Chapter 24. Introduction -- Chapter 25. Anti-Idiotypic Studies of the Glycoprotine B (gB, UL55) Complex of Human Cytomegalovirus: Mimicry of a Neutralizing Epitope and Development of Diagnostics -- Chapter 26. Anti-Idiotype Antibody in HIV- l-Infected Thrombocytopenic Patients -- Chapter 27. An Electron Microscopic View of the Geometry and Dynamics of Idiotype-Anti-Idiotype Interactions -- Chapter 28. Probing Human Antibody Diversity in HIV Infection -- Chapter 29. Anti-Idiotype Mimics of Pseudomonas Aeruginosa Surface Polysaccharides -- Chapter 30. Modulation of the Immune Response to Simian Virus 40 Large Tumor Antigen via Idiotype-Anti-Idiotype Interactions -- Chapter 31. The Perpetual Network Theory and its Putative Applications: 21 Years Later -- Chapter 32. An Anti-Idiotypic Antibody as a Functional Mirror Image of a Viral Antigen -- Chapter 33. Anti-Idiotype to Bluetongue Virus VP7 Antigen: Potential Diagnostic Reagent and Vaccine -- Chapter 34. An Idiotype Vaccine Against Gram-Negative Bacterial Sepsis -- Chapter 35. Yeast Killer Toxin-Like Antibodies in Experimental and Clinical Candidasis -- Chapter 36. Anti-Idiotypic Antibodies and Idiotypic T Cell Selection in HIV Infection -- 1. Idiotypes on HIV Specific Antibodies.

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