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Metastasis of breast cancer / par Mansel,, R.E. Publication : [S.l.] : Springer, 2007 . 435 p. ; , Metastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation. Written by experts in the subject area, the book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies. This timely book provides the current knowledge in the area of breast cancer metastasis and will be of important reading material for oncologists, radiologists, cancer researchers, biologists and health worker. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Nucleic acids hybridization : modern applications.   Publication : [S.l.] : Springer, 2007 . 316 p. ; , WatsonЀ“Crick hybridization of complementary sequences in nucleic acids is one of the most important processes necessary for molecular recognition in vivo, as well as nucleic acid identification and isolation. This book is devoted to a large family of in vitro DNA hybridization-based experimental techniques. A wide spectrum of experimental tasks covered by these approaches includes finding differential sequences in both genomic DNAs and mRNAs, genome walking, multiplex PCR, cDNA library construction starting from minute amount of total RNA, rapid amplification of cDNA 5Ѐ™ and 3Ѐ™ ends, effective smoothing of the concentrations of rare and abundant transcripts in cDNA libraries, recovery of promoter active repeats and differentially methylated genomic DNA, identification of common sequences in genomic or cDNA sources, new gene mapping, finding evolutionary conserved DNA and both single-nucleotide and extended mutation discovery or large-scale monitoring. Several approaches, such as microarray hybridization, have become extremely popular tools for specialists in biochemistry and in biomedicine, whereas the potential of many other advantageous techniques seems to be underestimated now. The international team of the authors of this book has tried both to elucidate the current state-of-art in hybridization techniques and to help the readers in choosing an appropriate method for performing an experiment in the most efficient way. Enclosed experimental protocols along with both comprehensive and detailed method descriptions make this truly universal book useful to all those interested in the modern life science methodologies. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Therapeutic neovascularization quo vadis?   Publication : [S.l.] : Springer, 2007 . 262 p. ; , The volume "Therapeutic Neovascularization: Quo Vadis?" picks up the current refinements in fundamental concept of neovascularization, which in the future might pave the way towards a new era of therapeutic applications. It meets an at times urgent need for treatment of patients who otherwise are not suitable for the established routines of percutaneous and surgical revascularization. At present most of the clinical trials initiated to promote neovascularization of ischemic myocardial or peripheral muscle tissue have failed to provide significant improvement of prespecified endpoints. This collection of manuscripts is selected to provide the most recent developments improving the auspices of successful revascularization therapy. Therefore, it covers sections such as the clinical challenge, novel mechanical and molecular concepts and cell therapy as an option, each composed of chapters written by experts in their fields. This collection of current and future concepts of neovascularization offers fascinating insights into refining a powerful therapeutic tool which has not yet had the chance to live up to the expectations and needs of the medical community. Indeed, the scientific modifications of a fundamentally sound concept will enable its applicability in the not so distant future. The condensed collection of current views on neovascularization is intended to speed up this process. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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