Bibliothèque de L'IMIST/CNRST

Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and pathology of bone Provides succinct coverage of the subject Contributors include over 200 of the most respected researchers in the field Extensive table of contents and index for easy reference Easy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacology Complete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996.

PART I: BASIC PRINCIPLES -- Cell Biology -- The Structure and Development of the Skeleton -- Biomechanics of Bone -- Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation -- Mesenchymal Stem Cells and Osteoblast Lineage -- Transcriptional Control of Osteoblast Differentiation and Function -- The Osteocyte -- Cells of Bone: Osteoclast Generation -- Osteoclast Function -- Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts -- Apoptosis in Bone Cells -- Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells -- Biochemistry -- Type I Collagen: Structure, Synthesis, and Regulation -- Collagen Crosslinking and Metabolism -- Bone Matrix Proteoglycans and Glycoproteins -- Osteopontin -- Bone Proteinases -- Cell Surface Attachment Molecules -- Intercellular Junctions and Cell-Cell Communication in Bone -- Bone Remodeling and Mineral Homeostasis -- Histomorphometric Analysis of Bone Remodeling -- Phosphorus Homeostasis and Related Disorders -- Magnesium Homeostasis -- Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, and Strontium -- The Biology of the Extracellular Ca2+-Sensing Receptor (CaR) -- The Hormones of Bone -- Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide -- Parathyroid Hormone -- Molecular Biology -- Parathyroid Hormone-Receptor Interactions -- Actions of Parathyroid Hormone -- Renal and Skeletal Actions of PTH and PTHrP -- Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues -- Vascular, Cardiovascular and Neurological Actions of PTHrP -- Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses -- Vitamin D Gene Regulation -- Photobiology and Non-Calcemic Actions of Vitamin D -- The Structure and Molecular Biology of the Calcitonin Receptor -- Physiology and Pathophysiology of Calcitonin -- Amylin and CGRP -- Other Systemic Hormones That Influence Bone Metabolism -- Estrogens and Progestins -- Selective Estrogen Receptor Modulators (SERMs) -- Mechanisms of Estrogen Action in Bone -- Thyroid Hormone and Bone -- Clinical and Basic Aspects of Glucocorticoid Action in Bone -- Effects of Diabetes and Insulin on Bone Physiology -- Androgens: Receptor Expression and Steroid Action in Bone -- Kinins and Neuro-Osteogenic Factors -- Local Regulators -- The Role of Insulin-like Growth Factors and Binding Proteins in Bone Cell Biology -- Platelet-Derived Growth Factor and the Skeleton -- Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone -- Vascular Endothelial Growth Factors -- Transforming Growth Factor (beta) -- Bone Morphogenetic Proteins -- Bone Morphogenetic Protein Receptors and Actions -- Colony-Stimulating Factors -- Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines -- Prostaglandins and Bone Metabolism -- Nitric Oxide and other Vasoactive Agents -- PART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASES -- Molecular Basis of PTH Overexpression -- Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism -- Multiple Endocrine Neoplasia Type I -- The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2 -- Systemic Factors in Skeletal Manifestations of Malignancy -- Local Factors in Skeletal Malignancy -- Molecular Basis of PTH Underexpression -- Jansen's Metaphyseal Chondrodysplasia and Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations -- Signal Transduction via G Proteins; Pseudohypoparathyroidism -- Other Skeletal Diseases Resulting from G Protein Defects -- Fibrous Dysplasia and McCune-Albright Syndrome -- Osteogenesis Imperfecta -- Hereditary Deficiencies in Vitamin D Action. -- Oncogenic Osteomalacia -- Osteopetrosis -- Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man -- Paget's Disease of Bone -- Genetic Determinants of Bone Mass -- Pathophysiology of Osteoporosis -- Evaluation of Risk for Osteoporosis Fractures -- PART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICS -- Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone -- Calcium -- Calcium Receptors as Novel Drug Targets -- Bisphosphonates: Mechanisms of Action -- Fluoride in Osteoporosis -- The Pharmacology of Estrogens in Osteoporosis -- Pharmacologic Mechanisms of Therapeutics: Vitamin D and Analogs -- Molecular and Clinical Pharmacology of Calcitonin -- Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases -- Anabolic Steroid Effects on Bone in Women -- Estrogen Effects on Bone in the Male Skeleton -- Mechanisms of Exercise Effects on Bone -- PART IV: METHODS IN BONE RESEARCH -- Application of Transgenic Mice to Problems of Skeletal Bone -- Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes -- Current Methodologic Issues in Cell and Tissue Culture -- Biochemical Markers of Bone Metabolism -- Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry -- Controversies in Bone Mass Measurement -- Macro and Micro Imaging of Bone Architecture -- Transilial Bone Biopsy -- Animal Models in Osteoporosis Research -- Defining the Genetics of Osteoporosis -- Using the Mouse to Understand Man.

Includes bibliographical references and index.

V. 1.-- Part. I. Basic principles -- V. 2.-- Part. II. Molecular mechanisims of metabolic bone diseases -- Part. III. Pharmacological mechanisms of therapeutics -- Part. IV. Methods in bone research.

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