Catalogue Bibliothèque de L'IMIST/CNRST › Résultats de la recherche pour 'ccl=su:Toxicology'

Antibiotics the perfect storm par Shlaes, David M. Publication : [S.l.] Springer 2010 . 106 p. , Antibiotics are truly miracle drugs. As a class, they are one of the only ones that actually cure disease as opposed to most drugs that only help relieve symptoms or control disease. Since bacteria that cause serious disease in humans are becoming more and more resistant to the antibiotics we have today, and because they will ultimately become resistant to any antibiotic that we use for treatment or for anything else, we need a steady supply of new antibiotics active against any resistant bacteria that arise. However, the antibiotics marketplace is no longer attractive for large pharmaceutical companies, the costs of development are skyrocketing because of ever more stringent requirements by the regulatory agencies, and finding new antibiotics active against resistant strains is getting harder and harder. These forces are all combining to deny us these miracle drugs when we need them the most. I provide a number of possible paths to shelter from this perfect storm. 24 cm. Date : 2010 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

		Pas d'image disponible Advances in molecular toxicology / Publication : Amsterdam ; \| Oxford : Elsevier, 2006 . 1 online resource (volumes <1>) : Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Analytical methods for therapeutic drug monitoring and toxicology / par Xu, Quanyun A., Publication : Hoboken, N.J. : Wiley, 2011 . xiv, 502 pages ; 28 cm Date : 2011 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Animal clinical chemistry a primer for toxicologists Publication : [S.l.] CRC Press 1996 . 224 p. , By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science. 25 cm. Date : 1996 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Antibiotics the perfect storm par Shlaes, David M. Publication : [S.l.] Springer 2010 . 106 p. , Antibiotics are truly miracle drugs. As a class, they are one of the only ones that actually cure disease as opposed to most drugs that only help relieve symptoms or control disease. Since bacteria that cause serious disease in humans are becoming more and more resistant to the antibiotics we have today, and because they will ultimately become resistant to any antibiotic that we use for treatment or for anything else, we need a steady supply of new antibiotics active against any resistant bacteria that arise. However, the antibiotics marketplace is no longer attractive for large pharmaceutical companies, the costs of development are skyrocketing because of ever more stringent requirements by the regulatory agencies, and finding new antibiotics active against resistant strains is getting harder and harder. These forces are all combining to deny us these miracle drugs when we need them the most. I provide a number of possible paths to shelter from this perfect storm. 24 cm. Date : 2010 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Anticholinesterase pesticides : metabolism, neurotoxicity, and epidemiology / Publication : Hoboken, N.J. : Wiley, 2010 . xviii, 625 pages : 28 cm Date : 2010 Disponibilité : Exemplaires disponibles: (), La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Biopharmaceutics applications in drug development Publication : [S.l.] Springer 2007 . 402 p. , In the last two decades, the discipline of biopharmaceutics has undergone considerable advances, particularly with regard to bioavailability and bioequivalence as they relate to product quality and regulatory standards of approval. Textbooks in the field have not been able to keep up with the growth of current and emerging applications of regulatory aspects of biopharmaceutics. Biopharmaceutics Applications in Drug Development fills this gap. This book introduces fundamental concepts, methods, and advances in the areas of dissolution, absorption, and permeability and their key applications in dosage form performance. Case studies are used to discuss the applications of biopharmaceutic strategies in the development of successful drugs, with a specific focus on the applications of biopharmaceutic strategies in the development of successful drugs. The book presents an integrated view in linking pharmaceutic to the biological consequences of drug products and leverages those for decision making in drug development. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Cardiovascular effects of inhaled ultrafine and nano-sized particles / Publication : Hoboken, N.J. : Wiley, 2011 . xviii, 585 pages : 25 cm Date : 2011 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Casarett and Doull's toxicology : the basic science of poisons / Publication : New York : McGraw-Hill Medical Pub. Division, 2001 . xix, 1236 p. : 29 cm. Date : 2001 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Chemical pesticides : mode of action and toxicology / par Stenersen,, J‚rgen. Publication : Boca Raton : CRC Press, 2004 . 276 p. : , "TF2265"--Cover p. 4. 25 cm. Date : 2004 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Chemical warfare agents toxicology and treatment Publication : Chichester Wiley 2007 . 738 p. , Chemical Warfare Agents, Second Edition has been totally revised since the successful first edition and expanded to about three times the length, with many new chapters and much more in-depth consideration of all the topics. The chapters have been written by distinguished international experts in various aspects of chemical warfare agents and edited by an experienced team to produce a clear review of the field. The book now contains a wealth of material on the mechanisms of action of the major chemical warfare agents, including the nerve agent cyclosarin, formally considered to be of secondary importance, as well as ricin and abrin. Chemical Warfare Agents, Second Edition discusses the physico-chemical properties of chemical warfare agents, their dispersion and fate in the environment, their toxicology and management of their effects on humans, decontamination and protective equipment. New chapters cover the experience gained after the use of sarin to attack travellers on the Tokyo subway and how to deal with the outcome of the deployment of riot control agents such as CS gas. This book provides a comprehensive review of chemical warfare agents, assessing all available evidence regarding the medical, technical and legal aspects of their use. It is an invaluable reference work for physicians, public health planners, regulators and any other professionals involved in this field. Review of the First Edition: "What more appropriate time for a title of this scope than in the post 9/11 era? ...a timely, scholarly, and well-written volume which offers much information of immense current and…future benefit." —VETERINARY AND HUMAN TOXICOLOGY. 26 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Cigarette smoke toxicity linking individual chemicals to human diseases / Publication : Weinheim : \| Chichester : Wiley-VCH ; \| [John Wiley [distributor], 2011 . 1 online resource (xx, 367 p.) : Date : 2011 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Pas d'image disponible Communicating toxicogenomics information to nonexperts : a workshop summary / par Nonexperts,, Committee on Communicating Toxicogenomics Information to. Publication : [S.l.] : National Academy Press, 2005 . 60 p. ; , BrochØ. 23 cm. Date : 2005 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Developmental neurotoxicology research : principles, models, techniques, strategies, and mechanisms / Publication : Hoboken, N.J. : Wiley, 2011 . xvii, 646 pages : 25 cm. Date : 2011 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Endotoxins : structure, function and recognition / Publication : [S.l.] Springer 2010 . 432 p. , Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells. 24 cm. Date : 2010 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Environmental health risks lead poisoning and arsenic exposure Publication : New York Nova Science Publishers 2009 . xi, 202 pages 27 cm. Date : 2009 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Fundamentals of toxicologic pathology Publication : Amsterdam Elsevier 2010 . 1 online resource (XXI, 691 S.) , Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology 2e updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practicioners, including diagnostic pathologistis and toxicologists. NOW FEATURING: . 25% brand new information, fully revised throughout . New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology . New color photomicrographs detailing specific toxicant-induced diseases in animals . Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels \| Previous edition: 1997 Date : 2010 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Genotoxic impurities : strategies for identification and control Publication : Hoboken, N.J. Wiley 2010 . xiii, 428 pages 25 cm. Date : 2010 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Goodman & gilman's the pharmacological basis of therapeutics / par Brunton,, Laurence. Publication : [S.l.] : McGraw-Hill Professional, 2005 . 1984 p. ; , A Doody's Core Title ESSENTIAL PURCHASE! 5 STAR DOODY'S REVIEW! "The 11th edition of Goodman & Gilman continues to be the most comprehensive and authoritative single source on the pharmacology of drugs. The first edition was published by Alfred Gilman and Louis Goodman in 1941. It soon became known as the bible of pharmacology and, even though editorship and chapter authorships have changed continuously from edition to edition, this remains the gold standard of pharmacology textbooks....The print version should be on the reference shelf and the digital version on the computer desktop of all practicing pharmacologists, pharmacists, and physicians."-- Doody's Review Service (20060801) 26 cm. Date : 2005 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Handbook of systems toxicology / Publication : Chichester, West Sussex : Wiley, 2011 . 2 Bde : Date : 2011 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)
		Handbook on the toxicology of metals, third edition Publication : [S.l.] Academic Press 2007 . 1024 p. , Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more. 29 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1), Réserver Ajouter au panier (Supprimer)

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