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Ecological developmental biology : integrating epigenetics, medicine, and evolution par Gilbert, Scott F. Publication : Sunderland, Mass. Sinauer Associates 2009 . xv, 480 pages , "When the molecular processes of epigenetics meet the ecological processes of phenotypic plasticity, the result is a revolutionary new field: ecological developmental biology, or "eco-devo." This new science studies development in the "real world" of predators, pathogens, competitors, symbionts, toxic compounds, temperature changes, and nutritional differences. These environmental agents can result in changes to an individual's phenotype, often implemented when signals from the environment elicit epigenetic changes in gene expression. Ecological developmental biology is a truly integrative biology, detailing the interactions between developing organisms and their environmental contexts. Ecological developmental biology also provides a systems approach to the study of pathology, integrating the studies of diabetes, cancers, obesity, and the aging syndrome into the framework of an ecologically sensitive developmental biology. It looks at examples where the environment provides expected cues for normal development and where the organism develops improperly without such cues. Data from research on teratology, endocrine disruptors, and microbial symbioses, when integrated into a developmental context, may have enormous implications for human health as well as the overall health of Earth's ecosystems. The study of epigenetics--changes in gene expression that are not the result of changes in a gene's DNA sequence--has recently provided startling insights not only into mechanisms of development, but also into the mechanisms and processes of evolution. The notion that epialleles (changes in chromosome structure that alter gene expression) can be induced by environmental agents and transmitted across generations has altered our notions of evolution, as have new experiments documenting the genetic fixation of environmentally induced changes in development. The widespread use of symbiosis in development provides new targets for natural selection. Ecological developmental biology integrates these new ideas into an extended evolutionary synthesis that retains and enriches the notion of evolution by natural selection."--Publisher's description. 24 cm. Date : 2009 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Gene expression and regulation par Ma, Jun. Publication : U.S.A. Springer 2006 . 582 p. , This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches. 29 cm. Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Introduction to genomic signal processing with control par Datta, Aniruddha Publication : Boca Raton CRC Press 2007 . xiv, 271 pages 25 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Microarrays / par Muller,, Hans-Joachim. Publication : Burlington, MA : Elsevier Academic Press, 2006 . xv, 212 p. : 26 cm. Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Physics in molecular biology / par Sneppen, Kim. Publication : Cambridge, UK ; | New York : Cambridge University Press, 2005 . viii, 311 p. ; 26 cm. Date : 2005 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Serial analysis of gene expression.   Publication : [S.l.] : Humana Press, 2007 . 208 p. ; , Serial Analysis of Gene Expression (SAGE): Digital Gene Expression Profiling facilitates the introduction of SAGE into the laboratory, and provides a framework for interpreting and comparing data derived from SAGE experiments. Of the several methods of genetic profiling available, only SAGE measures the expression of both known and unknown genes. SAGE studies encompass 50,000 tags and can provide detailed knowledge of the 2000 most highly expressed genes in the tissue sample. The SAGE protocols presented are detailed, fully annotated, and tested, and are all written by experienced SAGE researchers from around the world. Part 1 is dedicated to experimental procedures of SAGE and related methods including aRNA LongSAGE, SuperSAGE, DeepSAGE, and GMAT. Part 2 provides methods for extraction and filtration of tags, analysis of ditag populations, and completing statistically correct comparisons of gene expression profiles. Comparative transcriptomics enables scientists to understand the underlying genetics of biological changes such as development, disease, crop yield, and resistance. SAGE analysis is also used to obtain unknown tags, which can be used as gene-specific primers in Rapid Amplification of cDNA Ends (RACE) reactions to generate full-length transcripts for cloning and sequencing. This book will be an indispensable tool for any lab engaged in genetic profiling and comparative transcriptomics, and will help many laboratories to successfully implement tag-based sequencing methods and procedures and obtain comprehensive, useful, and interpretative data. 23 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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