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˜The œevolution of the genome /   Publication : . 1 online resource (xxvi, 740 pages) : , The Evolution of the Genome provides a much needed overview of genomic study through clear, detailed, expert-authored discussions of the key areas in genome biology. This includes the evolution of genome size, genomic parasites, gene and ancient genome duplications, polypoidy, comparative genomics, and the implications of these genome-level phenomena for evolutionary theory. In addition to reviewing the current state of knowledge of these fields in an accessible way, the various chapters also provide historical and conceptual background information, highlight the ways in which the critical questions are actually being studied, indicate some important areas for future research, and build bridges across traditional professional and taxonomic boundaries. The Evolution of the Genome will serve as a critical resource for graduate students, postdoctoral fellows, and established scientists alike who are interested in the issue of genome evolution in the broadest sense. Provides detailed, clearly written chapters authored by leading researchers in their respective fields Presents a much-needed overview of the historical and theoretical context of the various areas of genomic study Creates important links between topics in order to promote integration across subdisciplines, including descriptions of how each subject is actually studied Provides information specifically designed to be accessible to established researchers, postdoctoral fellows, and graduate students alike. Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),
A guinea pig's history of biology / par Endersby, Jim. Publication : [S.l.]: Harvard University Press, 2007 . 499 pages; , "Endless forms most beautiful and most wonderful have been, and are being, evolved," Darwin famously concluded The Origin of Species , and for confirmation we look to...the guinea pig? How this curious creature and others as humble (and as fast-breeding) have helped unlock the mystery of inheritance is the unlikely story Jim Endersby tells in this book. Biology today promises everything from better foods or cures for common diseases to the alarming prospect of redesigning life itself. Looking at the organisms that have made all this possible gives us a new way of understanding how we got here--and perhaps of thinking about where we're going. Instead of a history of which great scientists had which great ideas, this story of passionflowers and hawkweeds, of zebra fish and viruses, offers a bird's (or rodent's) eye view of the work that makes science possible. Mixing the celebrities of genetics, like the fruit fly, with forgotten players such as the evening primrose, the book follows the unfolding history of biological inheritance from Aristotle's search for the "universal, absolute truth of fishiness" to the apparently absurd speculations of eighteenth-century natural philosophers to the spectacular findings of our day--which may prove to be the absurdities of tomorrow. The result is a quirky, enlightening, and thoroughly engaging perspective on the history of heredity and genetics, tracing the slow, uncertain path--complete with entertaining diversions and dead ends--that led us from the ancient world's understanding of inheritance to modern genetics. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (4),

Abnormal skeletal phenotypes From simple signs to complex diagnoses par Castriota-Scanderbeg, Alessandro Publication : Berlin | New York Springer 2005 . xiv, 962 pages , Focuses on the radiographic changes of malformation syndromes and skeletal dysplasias. It is structured such that the reader can identify the radiographic changes and relate them to specific disease entities. The aim is to provide an essential, practical guideline to the recognition of the key radiographic signs for diagnosing malformation syndromes and skeletal dysplasias. The book is intended for radiologists, clinical and medical geneticists, and pediatricians. 28 cm. Date : 2005 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

Analysis of complex disease association studies a practical guide   Publication : [S.l.] Academic Press 2010 . 340 p. , According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. (good paragraph) This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. This book will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. * Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests * Extensive list of references including links to tutorial websites * Case studies and Tips and Tricks. 24 cm. Date : 2010 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),
Analysis of genes and genomes par Reece, Richard J. Publication : Chichester, West Sussex, England | Hoboken, NJ John Wiley and Sons 2004 . xix, 469 pages 25 cm. Date : 2004 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

Aquaculture and fisheries biotechnology : genetic approaches / par Dunham, Rex A. Publication : Wallingford, Oxfordshire, UK ; | Cambridge, MA : CABI, 2011 . viii, 495 pages : 25 cm Date : 2011 Disponibilité : Exemplaires disponibles: La bibliothèque des sciences de l'ingénieur (1),

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