Bibliothèque de L'IMIST/CNRST

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Biotransformations in organic chemistry : a textbook / par Faber, Kurt. Publication : [S.l.] : Springer, 2004 . 454 p. ; , The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry. Over the last two decades, this methodology has become an indispensable tool for asymmetric synthesis, not only at the academic level, but also on an industrial scale. This well-established textbook on biocatalysis provides a basis for undergraduate and graduate courses in modern organic chemistry, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts ? principles of stereoselective transformations, kinetics and enzyme properties ? the different types of reactions are explained according to the 'reaction principle', such as hydrolysis, reduction, oxidation, C-C bond formation, etc. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques and the use of modified enzymes, are treated in a separate section. A final chapter deals with the basic rules for the safe and practical handling of biocatalysts. In this revised and corrected 5th edition, emphasis has been given to an improved didactic style in order to facilitate a deeper understanding of the underlying principles. New developments, such as dynamic resolution, stereo-inversion and enantio-convergent processes are included. 23 cm. Date : 2004 Disponibilité : Exemplaires disponibles: La bibliothèque des sciences de l'ingénieur (1),

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Bone marrow and stem cell transplantation.   Publication : [S.l.] Humana Press 2007 . 234 p. , This volume is a compendium of cutting-edge molecular methods for the successful transplantation of hematopoietic stem cells. The availability of genetic profiles for committed and uncommitted stem cells combined with the determination of molecular steps involved in hematopoietic stem cell activation and self-renewal hold tremendous promise for future success in the clinic. Currently, stem cells can be quantified and sorted successfully, but transduction, labeling, and in vivo tracking of stem cells are difficult techniques with traditionally low efficiency levels. The contributors to this volume describe promising tools for stem cell transplant research models, such as in vivo bioluminescence imaging. Topics included in this volume are molecular profiling of hematopoietic stell cells, methods for imaging cell fates in hematopoiesis, PCR-SSP typing of HLA Class I and Class II alleles, sequence-based HLA typing, and typing minor HLA antigens. Also discussed in this volume are the roles of natural killer cells and killer inhibitor receptor polymorphisms, polymorphisms within epithelial receptors, molecular methods used for the detection of autologous graft contamination in lymphoid disorders, and the application of proteomics to posttransplantation follow-up. With the recent trend moving from gene expression to the protein expression profiles, the application of proteomics to the posttransplant follow-up of patients is becoming routine. As a result, this volume will become an invaluable source for biochemists, molecular biologists, and clinicians. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Brain imaging : the chemistry of mental activity / par Wagner, Henry N., Publication : London : Springer, 2009 . 1 online resource (xiii, 244 pages) : Date : 2009 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Metastasis of breast cancer / par Mansel,, R.E. Publication : [S.l.] : Springer, 2007 . 435 p. ; , Metastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation. Written by experts in the subject area, the book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies. This timely book provides the current knowledge in the area of breast cancer metastasis and will be of important reading material for oncologists, radiologists, cancer researchers, biologists and health worker. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Peroxiredoxin systems : structures and functions / par Flohé,, Leopold. Publication : [S.l.] : Springer, 2007 . 410 p. ; , The peroxiredoxins represent an important emerging family of sulfhydryl-linked antioxidant proteins, apparently ubiquitously present in all known organisms. The antioxidant function of the peroxiredoxins complements that of other enzymic and non-enzymic systems within the cell. In addition, there is increasing evidence that the peroxiredoxins play a role in cell signalling, by controlling and/or sensing hydrogen peroxide and peroxynitrite levels. In this, the first book containing a broad survey on the peroxiredoxins, the editors succeeded to involve almost all groups that contributed significant insights into the emerging field. The diverse biological roles of the new protein family are discussed in the context of other antioxidant systems like those based on heme or selenium catalysis. Finally, related future perspectives, which range from antimicrobial therapy up to the understanding of human development and carcinogenesis, are highlighted. Specifically, the book will be of outstanding interest to researchers who want to understand how micro-organisms, plants and animals cope with oxidative stress and how such stress is recognized and linked to adaptive responses via redox regulation of cellular processes. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Single molecule chemistry and physics : an introduction / par Wang,, Chen. Publication : [S.l.] : Springer, 2006 . 303 p. ; , The characterization of individual molecules has been a scientifically attractive and challenging task for decades, and remains so today. New technological developments have facilitated great progress in our understanding of the structure and behavior of single atoms and molecules in various environments. This book provides an introduction to the most important experimental and theoretical methods for characterizing and imaging single molecules, including scanning tunnelling and atomic force microscopy of molecules at surfaces, fluorescence studies, near-field optical microscopy and Raman spectroscopy. It also elucidates newly discovered properties of single-molecular systems and their relevance to the fast growing field of nanotechnology. 24 cm. Date : 2006 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Textbook of respiratory cell and molecular biology / par Wardlaw,, A. J. Publication : [S.l.] : Informa Healthcare, 2002 . 500 p. ; , The dramatic advances made in molecular science and genetics during the last two decades have started to transform our understanding of the scientific basis of human disease. We are now at the threshold of understanding, at the level of an individual protein or gene, what has gone wrong and how we might put it right. This is as true in respiratory disease as in other specialities. The genetic basis for cystic fibrosis is now clear and gene replacement therapy is a real possibility; analysis of the fine structure of *a1-antitrypsin has revealed how mutations cause disease; and the secrets of how respiratory syncytial virus causes bronchiolitis in children are being unlocked. However, as the literature expands at an exponential rate, clinicians who may have last studied immunology or genetics at medical school, or scientists new to respiratory research, can find it increasingly difficuly to keep up-to-date. This book is aimed primarily at those with a special interest in respiratory disease, either as physicians or scientists, who want a detailed but clear explanation of our current understanding of the pathogenesis of common respiratory disease. While the book makes no apologies for exploring in detail the scientific complexities that underpin respiratory disease, it will have failed if it is not also an enjoyable and stimulating read. Although much remains to be known, this book provides both a reference and a benchmark against which future progress can be measured. 25 cm. Date : 2002 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Exactes et Naturelles (1),

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Therapeutic neovascularization quo vadis?   Publication : [S.l.] : Springer, 2007 . 262 p. ; , The volume "Therapeutic Neovascularization: Quo Vadis?" picks up the current refinements in fundamental concept of neovascularization, which in the future might pave the way towards a new era of therapeutic applications. It meets an at times urgent need for treatment of patients who otherwise are not suitable for the established routines of percutaneous and surgical revascularization. At present most of the clinical trials initiated to promote neovascularization of ischemic myocardial or peripheral muscle tissue have failed to provide significant improvement of prespecified endpoints. This collection of manuscripts is selected to provide the most recent developments improving the auspices of successful revascularization therapy. Therefore, it covers sections such as the clinical challenge, novel mechanical and molecular concepts and cell therapy as an option, each composed of chapters written by experts in their fields. This collection of current and future concepts of neovascularization offers fascinating insights into refining a powerful therapeutic tool which has not yet had the chance to live up to the expectations and needs of the medical community. Indeed, the scientific modifications of a fundamentally sound concept will enable its applicability in the not so distant future. The condensed collection of current views on neovascularization is intended to speed up this process. 24 cm. Date : 2007 Disponibilité : Exemplaires disponibles: La bibliothèque des Sciences Médicales et Pharmaceutiques (1),

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Medical biochemistry / par Bhagavan, N. V. Publication : . 1 online resource (xxx, 1016 pages) : Disponibilité :  http://www.sciencedirect.com/science/book/9780120954407,

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