Makowski, Gregory.
Advances in Clinical Chemistry. - 1 online resource (285 pages) - Advances in Clinical Chemistry . - Advances in Clinical Chemistry. .
5. Conclusions.
Front Cover; Advances in Clinical Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Human Epididymis Protein 4 in Cancer Diagnostics: A Promising and Reliable Tumor Marker; 1. Introduction; 2. General Characteristics; 3. Analytical Methods; 3.1. Enzyme-linked immunosorbent assay; 3.2. Chemiluminescent microparticle immunoassay; 3.3. Bead-based array system; 4. Cancer Diagnostics; 4.1. Ovarian cancer; 4.2. Endometrial cancer; 4.3. Breast cancer; 4.4. Transitional cell carcinoma; 4.5. Lung cancer; 4.6. Pancreatic cancer; 4.7. Other tumors; 5. Discussion; References. Chapter Two: Pathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome1. Introduction; 2. Pathogenesis Underlying Myocardial Ischemia/Infarction; 3. Ideal Cardiac Biomarkers; 4. History of Cardiac Biomarkers; 5. Myocardial Dysfunction; 5.1. B-type natriuretic peptide; 6. Myocardial Necrosis; 6.1. Cardiac troponins; 6.2. Creatine kinase MB; 6.3. Myoglobin; 6.4. Heart-type fatty acid-binding protein; 7. Myocardial Ischemia; 7.1. Choline; 7.2. Ischemia-modified albumin; 8. Biomarkers of Inflammation; 8.1. Acute-phase response; 8.1.1. C-reactive protein. 8.2. Plaque rupture8.2.1. Pregnancy-associated plasma protein A; 8.2.2. Soluble CD40 ligand; 8.3. Plaque destabilization; 8.3.1. Matrix metalloproteinase 9; 8.3.2. Myeloperoxidase; 8.3.3. Neopterin; 9. Perspectives and Future Strategies; 10. Conclusion; References; Chapter Three: Paraoxonases: Ancient Substrate Hunters and Their Evolving Role in Ischemic Heart Disease; 1. Historical Overview: From Toxicology to Cardiovascular Disease; 2. The PON Enzyme Family; 2.1. Serum paraoxonase -- PON1: The best-known paraoxonase; 2.2. PON2 and PON3. 3. PON as Multitasking Enzymes: Pathways Related to Atherosclerosis3.1. Antioxidant function and protection; 3.2. PON1 and macrophage interaction in atherosclerosis; 3.3. Homocysteine-thiolactone: Vascular toxicity and inflammation; 3.4. PON and innate immunity: A new link to cardiovascular disease; 3.5. PON1: A possible determinant of clopidogrel efficacy; 3.6. PON2: Beyond intracellular antioxidant function; 4. PON and Ischemic Heart Disease: Animal Studies; 5. PON and Ischemic Heart Disease: Epidemiologic and Clinical Studies; 5.1. PON1 activities; 5.2. PON1 genotypes; 5.3. PON2 genotypes. 5.4. PON genotypes in genome-wide association studies6. PON1 as a Potential Therapeutic Tool; 7. Concluding Remarks; References; Chapter Four: Mucosal Healing in Ulcerative Colitis: Pathophysiology and Pharmacology; 1. Introduction; 2. Molecular Pathways of Intestinal Mucosal Wounding in Ulcerative Colitis; 2.1. Intrinsic molecular wound-healing pathways in epithelial cells; 2.2. Luminal factors; 2.3. Lamina propria: Epithelial cell interactions in wound healing; 3. Epithelial Healing in Ulcerative Colitis Has an Impact on Disease Course; 4. The Pharmacodynamics of Wound Healing.
Volume 59 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. Leading experts from academia and clinical laboratory science Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies.
9780124058521 (electronic bk.) 0124058523 (electronic bk.)
Clinical chemistry.
Biochemistry.
Biochemistry--Periodicals.
Clinical chemistry--Periodicals.
MEDICAL--Clinical Medicine.
SCIENCE--Chemistry--Clinical.
Biochemistry.
Clinical chemistry.
Electronic books.
RB1 .A2 2013
616.0756
Advances in Clinical Chemistry. - 1 online resource (285 pages) - Advances in Clinical Chemistry . - Advances in Clinical Chemistry. .
5. Conclusions.
Front Cover; Advances in Clinical Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Human Epididymis Protein 4 in Cancer Diagnostics: A Promising and Reliable Tumor Marker; 1. Introduction; 2. General Characteristics; 3. Analytical Methods; 3.1. Enzyme-linked immunosorbent assay; 3.2. Chemiluminescent microparticle immunoassay; 3.3. Bead-based array system; 4. Cancer Diagnostics; 4.1. Ovarian cancer; 4.2. Endometrial cancer; 4.3. Breast cancer; 4.4. Transitional cell carcinoma; 4.5. Lung cancer; 4.6. Pancreatic cancer; 4.7. Other tumors; 5. Discussion; References. Chapter Two: Pathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome1. Introduction; 2. Pathogenesis Underlying Myocardial Ischemia/Infarction; 3. Ideal Cardiac Biomarkers; 4. History of Cardiac Biomarkers; 5. Myocardial Dysfunction; 5.1. B-type natriuretic peptide; 6. Myocardial Necrosis; 6.1. Cardiac troponins; 6.2. Creatine kinase MB; 6.3. Myoglobin; 6.4. Heart-type fatty acid-binding protein; 7. Myocardial Ischemia; 7.1. Choline; 7.2. Ischemia-modified albumin; 8. Biomarkers of Inflammation; 8.1. Acute-phase response; 8.1.1. C-reactive protein. 8.2. Plaque rupture8.2.1. Pregnancy-associated plasma protein A; 8.2.2. Soluble CD40 ligand; 8.3. Plaque destabilization; 8.3.1. Matrix metalloproteinase 9; 8.3.2. Myeloperoxidase; 8.3.3. Neopterin; 9. Perspectives and Future Strategies; 10. Conclusion; References; Chapter Three: Paraoxonases: Ancient Substrate Hunters and Their Evolving Role in Ischemic Heart Disease; 1. Historical Overview: From Toxicology to Cardiovascular Disease; 2. The PON Enzyme Family; 2.1. Serum paraoxonase -- PON1: The best-known paraoxonase; 2.2. PON2 and PON3. 3. PON as Multitasking Enzymes: Pathways Related to Atherosclerosis3.1. Antioxidant function and protection; 3.2. PON1 and macrophage interaction in atherosclerosis; 3.3. Homocysteine-thiolactone: Vascular toxicity and inflammation; 3.4. PON and innate immunity: A new link to cardiovascular disease; 3.5. PON1: A possible determinant of clopidogrel efficacy; 3.6. PON2: Beyond intracellular antioxidant function; 4. PON and Ischemic Heart Disease: Animal Studies; 5. PON and Ischemic Heart Disease: Epidemiologic and Clinical Studies; 5.1. PON1 activities; 5.2. PON1 genotypes; 5.3. PON2 genotypes. 5.4. PON genotypes in genome-wide association studies6. PON1 as a Potential Therapeutic Tool; 7. Concluding Remarks; References; Chapter Four: Mucosal Healing in Ulcerative Colitis: Pathophysiology and Pharmacology; 1. Introduction; 2. Molecular Pathways of Intestinal Mucosal Wounding in Ulcerative Colitis; 2.1. Intrinsic molecular wound-healing pathways in epithelial cells; 2.2. Luminal factors; 2.3. Lamina propria: Epithelial cell interactions in wound healing; 3. Epithelial Healing in Ulcerative Colitis Has an Impact on Disease Course; 4. The Pharmacodynamics of Wound Healing.
Volume 59 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. Leading experts from academia and clinical laboratory science Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies.
9780124058521 (electronic bk.) 0124058523 (electronic bk.)
Clinical chemistry.
Biochemistry.
Biochemistry--Periodicals.
Clinical chemistry--Periodicals.
MEDICAL--Clinical Medicine.
SCIENCE--Chemistry--Clinical.
Biochemistry.
Clinical chemistry.
Electronic books.
RB1 .A2 2013
616.0756
