Genetic dissection of complex traits /
edited by D.C. Rao, C. Charles Gu.
- 2nd ed.
- 1 online resource (xxvii, 760 pages) : illustrations.
- Advances in genetics, v. 60 0065-2660 ; .
- Advances in genetics ; v. 60. .
Previous edition: 2001.
Includes bibliographical references and Index.
An overview of the genetic dissection of complex traits / Familial resemblance and heritability / Linkage and association: basic concepts / Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans / Karen Maresso and Ulrich Broeckel -- Genotyping errors and their impact on genetic analysis / Model-based methods for linkage analysis / Contemporary model-free methods for linkage analysis / DNA sequence-based phenotypic association analysis / D.C. Rao -- Treva K. Rice -- Ingrid B. Borecki and Michael A. Province -- Mary K. Wojczynski and Hemant K. Tiwari -- Michael B. Miller, Karen Schwander, and D.C. Rhao -- John P. Rice, Nancy L. Saccone, and Jonathan Corbett -- Laura Almasy and John Blangero -- Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo. 1. 2. 3. 4. Definition of phenotype / 5. 6. 7. 8. 9. Family-based methods for linkage and association analysis / Searching for additional disease loci in a genomic region / Methods for handling multiple testing / Meta-analysis methods / Haplotype-association analysis / Characterization LD structures and the utility of HapMap in genetic association studies / Associations among multiple markers and complex disease: models, algorithms, and applications / Nan M. Laird and Christoph Lange -- Glenys Thomson, Lisa F. Barcellos, and Ana M. Valdes -- Treva K. Rice, Nicholas J. Schork, and D.C. Rao -- Thomas A. Trikalinos, Georgia Salanti, Eias Zintzaras, and John P.A. Ioannidis -- Nianjun Liu, Kui Zhang, and Hongyu Zhao -- C. Charles Gu, Kai Yu, and D.C. Rao -- Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan, and Richard A. Olshen. 10. 11. 12. 13. 14. 15. 16. Study designs for genome-wide association studies / Ethical, legal, and social implications of biobanks for genetics research / Admixture mapping and the role of population structure for localizing disease genes / Integrating global gene expression analysis and genetics / A systems biology approach to drug discovery / The promise of composite likelihood methods for addressing computationally intensive challenges / Comparative genomics for detecting human disease genes / From genetics to mechanism of disease liability / Into the Post-HapMap era / Peter Kraft and David G. Cox -- Susanne B. Haga and Laura M. Beskow -- Xiaofeng Zhu, Hua Tang, and Neil Risch -- Clarles R. Farber and Aldons J. Lusis -- Jun Zhu, Bin Zhang, and Eric E. Schadt -- Na Li -- Carol Moreno, Jozef Lazar, Howard J. Jacob, and Anne E. Kwitek -- Andreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel -- Newton E. Morton. 17. 18. 19. 20. 21. 22. 23 24. 25.
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
9780080569116 (electronic bk.) 0080569110 (electronic bk.) 0123738830 (electronic bk.) 9780123738837 (electronic bk.)
Medical genetics.
Syndromes--Genetic aspects.
Genetic epidemiology.
HEALTH & FITNESS--Diseases--Genetic.
MEDICAL--Genetics.
Electronic books.
Genetica.
Electronic books.
QH431.A1 / A3 2008eb
616.042
RB155 / .G464 2008
QZ 50
Previous edition: 2001.
Includes bibliographical references and Index.
An overview of the genetic dissection of complex traits / Familial resemblance and heritability / Linkage and association: basic concepts / Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans / Karen Maresso and Ulrich Broeckel -- Genotyping errors and their impact on genetic analysis / Model-based methods for linkage analysis / Contemporary model-free methods for linkage analysis / DNA sequence-based phenotypic association analysis / D.C. Rao -- Treva K. Rice -- Ingrid B. Borecki and Michael A. Province -- Mary K. Wojczynski and Hemant K. Tiwari -- Michael B. Miller, Karen Schwander, and D.C. Rhao -- John P. Rice, Nancy L. Saccone, and Jonathan Corbett -- Laura Almasy and John Blangero -- Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo. 1. 2. 3. 4. Definition of phenotype / 5. 6. 7. 8. 9. Family-based methods for linkage and association analysis / Searching for additional disease loci in a genomic region / Methods for handling multiple testing / Meta-analysis methods / Haplotype-association analysis / Characterization LD structures and the utility of HapMap in genetic association studies / Associations among multiple markers and complex disease: models, algorithms, and applications / Nan M. Laird and Christoph Lange -- Glenys Thomson, Lisa F. Barcellos, and Ana M. Valdes -- Treva K. Rice, Nicholas J. Schork, and D.C. Rao -- Thomas A. Trikalinos, Georgia Salanti, Eias Zintzaras, and John P.A. Ioannidis -- Nianjun Liu, Kui Zhang, and Hongyu Zhao -- C. Charles Gu, Kai Yu, and D.C. Rao -- Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan, and Richard A. Olshen. 10. 11. 12. 13. 14. 15. 16. Study designs for genome-wide association studies / Ethical, legal, and social implications of biobanks for genetics research / Admixture mapping and the role of population structure for localizing disease genes / Integrating global gene expression analysis and genetics / A systems biology approach to drug discovery / The promise of composite likelihood methods for addressing computationally intensive challenges / Comparative genomics for detecting human disease genes / From genetics to mechanism of disease liability / Into the Post-HapMap era / Peter Kraft and David G. Cox -- Susanne B. Haga and Laura M. Beskow -- Xiaofeng Zhu, Hua Tang, and Neil Risch -- Clarles R. Farber and Aldons J. Lusis -- Jun Zhu, Bin Zhang, and Eric E. Schadt -- Na Li -- Carol Moreno, Jozef Lazar, Howard J. Jacob, and Anne E. Kwitek -- Andreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel -- Newton E. Morton. 17. 18. 19. 20. 21. 22. 23 24. 25.
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
9780080569116 (electronic bk.) 0080569110 (electronic bk.) 0123738830 (electronic bk.) 9780123738837 (electronic bk.)
Medical genetics.
Syndromes--Genetic aspects.
Genetic epidemiology.
HEALTH & FITNESS--Diseases--Genetic.
MEDICAL--Genetics.
Electronic books.
Genetica.
Electronic books.
QH431.A1 / A3 2008eb
616.042
RB155 / .G464 2008
QZ 50
