Bibliothèque de L'IMIST/CNRST

Includes bibliographical references and index.

Plaques and tangles in Alzheimer's disease : a historical introduction / Frank Ashall -- Structure, biochemistry and molecular pathogenesis of paired helical filaments in Alzheimer's disease / Claude M. Wischik, Robert Lai, Charles R. Harrington, Elizabeta B. Mukaetova-Ladinska, John H. Xuereb, Raul Mena, Patricia C. Edwards and Martin Roth -- Tau proteins and their significance in the pathobiology of Alzheimer's disease / Virginia M.-Y. Lee and John Q. Trojanowski -- The genetics of Alzheimer's disease and mutations in the amyloid [beta]-protein precursor gene / Frances Busfield and Alison M. Goate -- Transcriptional control of amyloid [beta]-protein precursor expression / Wolfgang W. Quitschke and Dmitry Goldgaber -- Post-translational control of the amyloid [beta]-protein precursor processing / Joseph D. Buxbaum -- Processing of the amyloid [beta]-protein precursor / Todd E. Golde and Steven G. Younkin -- Neurotoxicity of amyloid [beta]-protein and the amyloid [beta]-protein precursor / Kazuaki Yoshikawa -- Biological functions of the amyloid [beta]-protein precursor / Steven L. Wagner -- Cellular and animal models of amyloid [beta]-protein amyloidosis / Sangram S. Sisodia, David R. Borchelt and Donald L. Price -- Relationship of plaques and tangles to Alzheimer's disease phenotype / John C. Morris -- Apolipoprotein E and Alzheimer's disease / Judes Poirier, Josephine Nalbantoglu, Daniel Guillaume and Philippe Bertrand.

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field. With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease. Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research. * * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective * A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease. * Up-to-date research data * Clear illustrations complement the text.

Description based on print version record.