Bibliothèque de L'IMIST/CNRST

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. In this Part A volume, outstanding and original reviews provide an overview and synthesis of the latest thoughts and findings relating to Clusterin. Chapters include the shifiting balance between CLU Forms during tumor progression, uclear CLU and the fate of the cell, and Oxidative stress in malignant progression.

Includes bibliographical references and index.

Clusterin (CLU): from one gene and two transcripts to many proteins / Federica Rizzi, Mariangela Coletta, and Saverio Bettuzzi -- The shifting balance between CLU forms during tumor progression / Sabina Pucci and Saverio Bettuzzi -- Regulation of clusterin activity by calcium / Beata Pajak and Arkadiusz Orzechowski -- Nuclear CLU (nCLU) and the fate of the cell / Saverio Bettuzzi and Federica Rizzi -- The chaperone action of clusterin and its putative role in quality control of extracellular protein folding / Amy Wyatt ... [and others] -- Cell protective functions of secretory clusterin (sCLU) / Gerd Klock, Markus Baiersdörfer, and Claudia Koch-Brandt -- Clusterin: a multifacet protein at the crossroad of inflammation and autoimmunity / Géraldine Falgarone and Gilles Chiocchia -- Oxidative stress in malignant progression: the role of clusterin, a sensitive cellular biosensor of free radicals / Ioannis P. Trougakos and Efstathios S. Gonos.